Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   FE90_RS06435 Genome accession   NZ_CP008695
Coordinates   1253517..1254278 (-) Length   253 a.a.
NCBI ID   WP_011106593.1    Uniprot ID   P0DC31
Organism   Streptococcus pyogenes strain M23ND     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1248517..1259278
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FE90_RS06415 (FE90_1276) - 1248832..1250058 (-) 1227 WP_002986020.1 cysteine desulfurase -
  FE90_RS06420 (FE90_1277) sufD 1250089..1251351 (-) 1263 WP_038433592.1 Fe-S cluster assembly protein SufD -
  FE90_RS06425 (FE90_1278) sufC 1251446..1252216 (-) 771 WP_038433593.1 Fe-S cluster assembly ATPase SufC -
  FE90_RS06430 (FE90_1280) - 1252341..1253510 (-) 1170 WP_038433594.1 glycosyltransferase family 4 protein -
  FE90_RS06435 (FE90_1281) mecA 1253517..1254278 (-) 762 WP_011106593.1 adaptor protein MecA Regulator
  FE90_RS06440 (FE90_1282) - 1254424..1255263 (-) 840 WP_002986031.1 undecaprenyl-diphosphate phosphatase -
  FE90_RS06445 (FE90_1283) - 1255329..1257254 (-) 1926 WP_038433595.1 DUF2207 domain-containing protein -
  FE90_RS06450 (FE90_1284) - 1257452..1259020 (+) 1569 WP_038433596.1 ABC transporter substrate-binding protein/permease -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29051.68 Da        Isoelectric Point: 4.1282

>NTDB_id=108145 FE90_RS06435 WP_011106593.1 1253517..1254278(-) (mecA) [Streptococcus pyogenes strain M23ND]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEQIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=108145 FE90_RS06435 WP_011106593.1 1253517..1254278(-) (mecA) [Streptococcus pyogenes strain M23ND]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAACAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCCACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterProScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0DC31

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.2

98.814

0.625
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

48.627

100

0.49
  mecA Streptococcus pneumoniae D39

48.627

100

0.49
  mecA Streptococcus pneumoniae R6

48.627

100

0.49
  mecA Streptococcus pneumoniae TIGR4

48.627

100

0.49

Multiple sequence alignment