Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   ACKWPP_RS10075 Genome accession   NZ_CP176418
Coordinates   1987151..1987873 (-) Length   240 a.a.
NCBI ID   WP_002938171.1    Uniprot ID   A0A116M1G6
Organism   Streptococcus suis strain KKAHC02     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1982151..1992873
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACKWPP_RS10055 (ACKWPP_10055) - 1982223..1983446 (-) 1224 WP_409373907.1 cysteine desulfurase -
  ACKWPP_RS10060 (ACKWPP_10060) sufD 1983450..1984712 (-) 1263 WP_024385161.1 Fe-S cluster assembly protein SufD -
  ACKWPP_RS10065 (ACKWPP_10065) sufC 1984729..1985502 (-) 774 WP_002938165.1 Fe-S cluster assembly ATPase SufC -
  ACKWPP_RS10070 (ACKWPP_10070) - 1985982..1987154 (-) 1173 WP_012027769.1 glycosyltransferase family 4 protein -
  ACKWPP_RS10075 (ACKWPP_10075) mecA 1987151..1987873 (-) 723 WP_002938171.1 adaptor protein MecA Regulator
  ACKWPP_RS10080 (ACKWPP_10080) - 1988001..1988837 (-) 837 WP_015647359.1 undecaprenyl-diphosphate phosphatase -
  ACKWPP_RS10085 (ACKWPP_10085) - 1988964..1990529 (+) 1566 WP_024414457.1 ABC transporter substrate-binding protein/permease -
  ACKWPP_RS10090 (ACKWPP_10090) - 1990522..1991265 (+) 744 WP_012775335.1 amino acid ABC transporter ATP-binding protein -
  ACKWPP_RS10095 (ACKWPP_10095) - 1991388..1991597 (-) 210 WP_009910800.1 hypothetical protein -
  ACKWPP_RS10100 (ACKWPP_10100) - 1991683..1992585 (-) 903 WP_002942264.1 SPFH domain-containing protein -

Sequence

Protein


Download         Length: 240 a.a.        Molecular weight: 27973.51 Da        Isoelectric Point: 4.0497

>NTDB_id=1080084 ACKWPP_RS10075 WP_002938171.1 1987151..1987873(-) (mecA) [Streptococcus suis strain KKAHC02]
MKVKQISDSTLKITIKLDDLEERGMELSDFLIPQEKTEEFFYTVLDELDLPMTFRESGMLSFRVTPKPDRVDIFVTKSDL
DQSLNFDEFTDLSELGDVASMTPDEFFKSLEQTVREKSAPDATAVRHLEEVEQEEEADEEEQERYIYYILEFPTIEDLFT
FVGTVDYPVEESELYKMDGHYYLTVLINVENRSKQYPGYILSRMLEFTNDTKLTRPALQEHGTLMLPLAAIEELRKVPTV

Nucleotide


Download         Length: 723 bp        

>NTDB_id=1080084 ACKWPP_RS10075 WP_002938171.1 1987151..1987873(-) (mecA) [Streptococcus suis strain KKAHC02]
ATGAAAGTAAAGCAAATTAGTGATTCGACCTTGAAAATCACTATAAAATTAGATGATTTGGAAGAGAGAGGAATGGAACT
TTCGGACTTTCTCATTCCGCAAGAAAAGACAGAGGAGTTCTTCTATACTGTTTTGGATGAATTGGATTTACCAATGACTT
TCCGAGAAAGCGGTATGCTGAGTTTTCGTGTGACTCCGAAGCCAGATCGGGTGGACATCTTTGTTACCAAATCTGATTTG
GATCAGAGCTTGAATTTCGATGAATTTACAGATTTGTCGGAACTTGGTGATGTCGCAAGTATGACTCCAGATGAGTTTTT
CAAGAGTTTGGAGCAAACCGTTCGTGAGAAAAGCGCACCGGATGCAACAGCCGTTCGTCATTTGGAAGAGGTAGAGCAAG
AGGAAGAAGCAGATGAAGAGGAGCAGGAGCGCTATATTTACTATATTTTGGAATTTCCAACGATAGAGGATCTGTTTACT
TTTGTTGGTACGGTTGATTATCCAGTAGAAGAATCGGAATTATATAAAATGGATGGTCACTACTACTTGACCGTTCTTAT
CAATGTAGAAAATCGTTCCAAGCAGTATCCAGGCTACATTCTTTCAAGAATGTTGGAATTTACCAATGATACTAAGTTGA
CCAGACCTGCTTTACAAGAACACGGAACTTTGATGCTTCCGCTTGCGGCAATCGAGGAGCTTAGGAAGGTTCCGACAGTA
TGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-234)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A116M1G6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

51.639

100

0.525
  mecA Streptococcus pneumoniae D39

51.639

100

0.525
  mecA Streptococcus pneumoniae R6

51.639

100

0.525
  mecA Streptococcus pneumoniae TIGR4

51.639

100

0.525
  mecA Streptococcus mutans UA159

50

100

0.508
  mecA Streptococcus thermophilus LMD-9

47.5

100

0.475
  mecA Streptococcus thermophilus LMG 18311

47.083

100

0.471

Multiple sequence alignment