Detailed information NTG1077612

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: ACJKN5_RS04080
• Genome accession: NZ_CP174516
• Coordinates: 790598..791737 (+)
• Length: 379 a.a.
• NCBI ID: WP_014325193.1
• Uniprot ID: A0A5M8XCI1
• Organism: Leuconostoc mesenteroides strain HY303
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 785598..796737

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACJKN5_RS04060	yycF	785755..786462 (+)	708	WP_010281559.1	response regulator YycF	-
ACJKN5_RS04065	walK	786530..788395 (+)	1866	WP_025268546.1	cell wall metabolism sensor histidine kinase WalK	-
ACJKN5_RS04070	-	788385..789677 (+)	1293	WP_025268545.1	hypothetical protein	-
ACJKN5_RS04075	yycI	789734..790537 (+)	804	WP_010289058.1	two-component system regulatory protein YycI	-
ACJKN5_RS04080	htrA	790598..791737 (+)	1140	WP_014325193.1	S1C family serine protease	Regulator
ACJKN5_RS04085	rlmH	792367..792846 (+)	480	WP_011680487.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACJKN5_RS04090	-	792940..795105 (+)	2166	WP_025268544.1	YhgE/Pip domain-containing protein	-
ACJKN5_RS04095	-	795159..795611 (+)	453	WP_011680485.1	Rrf2 family transcriptional regulator	-
ACJKN5_RS04100	-	795696..796361 (-)	666	WP_010285559.1	NAD(P)H-hydrate epimerase	-

Sequence

Protein

• Length: 379 a.a.
• Molecular weight: 39210.48 Da
• Isoelectric Point: 9.7777

>NTDB_id=1077612 ACJKN5_RS04080 WP_014325193.1 790598..791737(+) (htrA) [Leuconostoc mesenteroides strain HY303]
MVQSALTKTLLTGVIAGVVGGGAILYGQQGVQLLQNQNQKVSTTATSTKTIAKNATATSAYNKVSDAVVSVLNFTKSSQG
SYQESSEGSGVIYKKTDGSAFIVTNNHVITGAAKIQVMLHSGKKVTATLVGKDAMTDLAVLKIDGTDVTTTAQFGDSSKI
TVGENVLAIGSPLGSEYASSVTQGIISAKKRLVEATSENGQNYGGSTVIQTDAAINPGNSGGPLINFAGQVIGINSMKLS
TSSSGTSVEGMGFAIPSDQVVDIVNKLVKDGKVTRPAIGISLINLSEVTASEQKSTLKIPDSVTGGVVVMSLTNNGPADK
AGLKKYDVIVGINGKKVSSQADLREELYKHSLGDTITLTYYHQDTKQTVKVKLTQKLAS

Nucleotide

• Length: 1140 bp

>NTDB_id=1077612 ACJKN5_RS04080 WP_014325193.1 790598..791737(+) (htrA) [Leuconostoc mesenteroides strain HY303]
ATGGTACAATCAGCATTAACAAAAACGTTGTTAACTGGCGTCATTGCTGGTGTTGTTGGTGGAGGAGCAATTTTGTATGG
GCAGCAGGGTGTACAATTGTTACAAAATCAAAATCAAAAAGTGAGTACGACAGCAACAAGTACAAAAACGATTGCCAAGA
ATGCAACTGCTACATCAGCTTATAATAAGGTATCAGATGCAGTTGTATCTGTATTGAACTTTACTAAATCCAGTCAAGGT
AGTTATCAAGAATCGTCAGAAGGTTCTGGCGTGATCTATAAAAAAACGGATGGATCGGCATTTATTGTAACGAATAATCA
CGTAATCACTGGAGCGGCTAAAATTCAAGTTATGCTGCACAGTGGGAAGAAAGTGACCGCTACATTAGTCGGCAAAGATG
CGATGACTGACTTAGCTGTTCTGAAAATCGACGGCACAGACGTTACAACAACTGCACAATTTGGCGATTCAAGTAAAATA
ACTGTTGGTGAAAATGTCTTGGCAATTGGTTCGCCGCTGGGATCTGAGTATGCTTCGTCAGTGACGCAAGGCATCATTTC
GGCCAAGAAAAGGTTAGTTGAGGCAACATCTGAAAATGGTCAAAATTATGGTGGATCCACGGTTATTCAGACGGATGCTG
CTATTAATCCTGGTAACTCAGGTGGACCATTAATCAACTTTGCAGGACAAGTTATTGGTATTAACTCAATGAAGTTATCA
ACATCTTCTTCTGGAACGAGCGTTGAGGGGATGGGTTTTGCAATTCCTTCTGATCAAGTCGTTGACATTGTTAACAAATT
AGTCAAAGATGGTAAAGTCACACGACCAGCAATTGGCATTAGTTTGATTAATTTGTCAGAAGTAACAGCTTCTGAGCAAA
AATCAACACTGAAAATTCCAGATAGCGTTACTGGTGGTGTTGTTGTAATGAGTTTGACTAACAATGGCCCAGCAGATAAA
GCTGGATTGAAGAAGTACGACGTTATTGTTGGCATTAATGGTAAAAAGGTCAGCTCACAGGCTGATCTGCGAGAAGAACT
CTACAAGCATTCGCTTGGGGACACAATAACATTGACTTATTATCATCAGGATACTAAGCAAACCGTCAAGGTTAAATTAA
CACAGAAATTGGCAAGCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (276-373)

• Peptidase family M50 (Peptidase_M50) (221-375)

• Trypsin-like peptidase domain (Trypsin_2) (88-234)

3D structure

• AlphaFold DB: A0A5M8XCI1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	52.394	93.668	0.491
htrA	Streptococcus gordonii str. Challis substr. CH1	48.549	100	0.485
htrA	Streptococcus pneumoniae D39	52.924	90.237	0.478
htrA	Streptococcus pneumoniae TIGR4	52.924	90.237	0.478
htrA	Streptococcus pneumoniae R6	52.924	90.237	0.478
htrA	Streptococcus pneumoniae Rx1	52.924	90.237	0.478
htrA	Streptococcus mutans UA159	52.647	89.71	0.472