Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   ACIVIR_RS07680 Genome accession   NZ_CP173225
Coordinates   1490511..1491215 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 262     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1485511..1496215
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACIVIR_RS07650 - 1485700..1486686 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  ACIVIR_RS07655 - 1486949..1487722 (-) 774 WP_044811410.1 potassium channel family protein -
  ACIVIR_RS07660 - 1487769..1488023 (-) 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin -
  ACIVIR_RS07665 relB 1488025..1488267 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  ACIVIR_RS07670 vicX 1488358..1489167 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  ACIVIR_RS07675 micB 1489169..1490518 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ACIVIR_RS07680 micA 1490511..1491215 (-) 705 WP_000722076.1 response regulator YycF Regulator
  ACIVIR_RS07685 mutY 1491270..1492445 (-) 1176 WP_000886125.1 A/G-specific adenine glycosylase -
  ACIVIR_RS07690 - 1492774..1494444 (-) 1671 WP_000845292.1 formate--tetrahydrofolate ligase -
  ACIVIR_RS07695 coaB 1494674..1495363 (+) 690 WP_000699498.1 phosphopantothenate--cysteine ligase -
  ACIVIR_RS07700 coaC 1495375..1495926 (+) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=1070818 ACIVIR_RS07680 WP_000722076.1 1490511..1491215(-) (micA) [Streptococcus pneumoniae strain 262]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=1070818 ACIVIR_RS07680 WP_000722076.1 1490511..1491215(-) (micA) [Streptococcus pneumoniae strain 262]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGCACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment