Detailed information NTG1070813

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: ACIVIR_RS06450
• Genome accession: NZ_CP173225
• Coordinates: 1239288..1241528 (+)
• Length: 746 a.a.
• NCBI ID: WP_044727637.1
• Uniprot ID: A0A0U0ERK9
• Organism: Streptococcus pneumoniae strain 262
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1234288..1246528

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACIVIR_RS06420	-	1234439..1235407 (+)	969	WP_000658183.1	PhoH family protein	-
ACIVIR_RS06425	-	1235600..1236100 (+)	501	WP_000566982.1	GNAT family N-acetyltransferase	-
ACIVIR_RS06430	-	1236103..1236428 (+)	326	Protein_1225	TfoX/Sxy family protein	-
ACIVIR_RS06435	ald	1236729..1237840 (-)	1112	Protein_1226	alanine dehydrogenase	-
ACIVIR_RS06440	-	1238017..1238586 (+)	570	WP_114880827.1	GNAT family N-acetyltransferase	-
ACIVIR_RS06445	comEA/celA/cilE	1238654..1239304 (+)	651	WP_114880828.1	helix-hairpin-helix domain-containing protein	Machinery gene
ACIVIR_RS06450	comEC/celB	1239288..1241528 (+)	2241	WP_044727637.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
ACIVIR_RS06455	-	1241707..1241895 (+)	189	WP_001809102.1	hypothetical protein	-
ACIVIR_RS06460	-	1241927..1242514 (+)	588	WP_000933542.1	ATP-binding cassette domain-containing protein	-
ACIVIR_RS06465	-	1242518..1243698 (+)	1181	Protein_1232	hypothetical protein	-
ACIVIR_RS06470	infC	1244005..1244535 (+)	531	WP_000848180.1	translation initiation factor IF-3	-
ACIVIR_RS06475	rpmI	1244568..1244768 (+)	201	WP_001125943.1	50S ribosomal protein L35	-
ACIVIR_RS06480	rplT	1244820..1245179 (+)	360	WP_000124836.1	50S ribosomal protein L20	-
ACIVIR_RS06485	-	1245237..1245617 (+)	381	WP_000157154.1	VOC family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84541.16 Da
• Isoelectric Point: 9.7665

>NTDB_id=1070813 ACIVIR_RS06450 WP_044727637.1 1239288..1241528(+) (comEC/celB) [Streptococcus pneumoniae strain 262]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKKIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLNTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVARRPLVFGQPNAWLLILLLISLALVYDLRKNIKGLTVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIKKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
EHVGDLSEMTKAFHVGEILVSKDSLKQKEFVAELQATQTKVRSMIVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=1070813 ACIVIR_RS06450 WP_044727637.1 1239288..1241528(+) (comEC/celB) [Streptococcus pneumoniae strain 262]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCTTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAAAAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGTAATTACATGA
CAGGACTCTTGCTGGGACATCTGAACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTAGAGGGCATTATTCGCTTGGT
CTCGCAGGTGGCAAGGAGACCGCTTGTCTTTGGTCAACCCAACGCATGGCTTTTAATCTTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAGGATTAACAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCCTTACCAAG
TATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCAAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CCCAGCGAACCTTGATTCCCTATCTCAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAGCATGTTGGAGATTTGTCAGAGATGACCAAGGCTTTCCATGTAGGGGAGATTCTAGTATCAAAAGACAGTCTGAAACA
GAAGGAATTTGTGGCAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGATAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTATCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

• Competence protein (Competence) (216-458)

• Domain of unknown function (DUF4131) (DUF4131) (30-177)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-693)

3D structure

• AlphaFold DB: A0A0U0ERK9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus pneumoniae TIGR4	99.33	100	0.993
comEC/celB	Streptococcus pneumoniae Rx1	97.989	100	0.98
comEC/celB	Streptococcus pneumoniae D39	97.989	100	0.98
comEC/celB	Streptococcus pneumoniae R6	97.989	100	0.98
comEC/celB	Streptococcus mitis SK321	92.359	100	0.924
comEC/celB	Streptococcus mitis NCTC 12261	91.812	99.866	0.917
comEC	Lactococcus lactis subsp. cremoris KW2	44.399	99.33	0.441