Detailed information NTG0106635

Bioinformatically predicted

Overview

• Name: comC/comC2
• Type: Regulator
• Locus tag: AABJ45_RS11480
• Genome accession: NZ_AP028611
• Coordinates: 2240416..2240541 (-)
• Length: 41 a.a.
• NCBI ID: WP_000799686.1
• Uniprot ID: P60242
• Organism: Streptococcus pneumoniae strain Sep6
• Function: binding to ComD; induce autophosphorylation of ComD (predicted from homology) Competence regulation

Genomic Context

Location: 2235416..2245541

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AABJ45_RS11450 (TKY121527_22350)	-	2236291..2236833 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
AABJ45_RS11465 (TKY121527_22360)	-	2237380..2238333 (+)	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-
AABJ45_RS11470 (TKY121527_22370)	comE	2238336..2239073 (-)	738	WP_338372085.1	competence system response regulator transcription factor ComE	Regulator
AABJ45_RS11475 (TKY121527_22380)	comD/comD2	2239070..2240395 (-)	1326	WP_000364845.1	competence system sensor histidine kinase ComD	Regulator
AABJ45_RS11480	comC/comC2	2240416..2240541 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
AABJ45_RS11490 (TKY121527_22390)	rlmH	2240823..2241302 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
AABJ45_RS11495 (TKY121527_22400)	htrA	2241485..2242666 (+)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
AABJ45_RS11500 (TKY121527_22410)	spo0J	2242724..2243482 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 41 a.a.
• Molecular weight: 4907.00 Da
• Isoelectric Point: 11.0006

>NTDB_id=106635 AABJ45_RS11480 WP_000799686.1 2240416..2240541(-) (comC/comC2) [Streptococcus pneumoniae strain Sep6]
MKNTVKLEQFVALKEKDLQKIKGGEMRISRIILDFLFLRKK

Nucleotide

• Length: 126 bp

>NTDB_id=106635 AABJ45_RS11480 WP_000799686.1 2240416..2240541(-) (comC/comC2) [Streptococcus pneumoniae strain Sep6]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

• COMC family (ComC) (1-29)

3D structure

• PDB: 6CJ8
• PDB: 6COO
• PDB: 6COP
• PDB: 6COQ
• PDB: 6COR
• PDB: 6COS
• PDB: 6COW
• PDB: 6OBW
• PDB: 6OC2
• PDB: 6OC4
• PDB: 6OLD
• PDB: 6V1N

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comC/comC2	Streptococcus pneumoniae A66	100	100	1
comC/comC2	Streptococcus pneumoniae TIGR4	100	100	1
comC/comC1	Streptococcus pneumoniae R6	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae G54	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae D39	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae Rx1	80.488	100	0.805
comC	Streptococcus mitis SK321	75.61	100	0.756
comC	Streptococcus mitis NCTC 12261	57.5	97.561	0.561