Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   AABA14_RS03745 Genome accession   NZ_AP028607
Coordinates   724289..724963 (+) Length   224 a.a.
NCBI ID   WP_042516090.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain Sep2     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 719289..729963
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AABA14_RS03725 (TKY123642_07190) - 719457..720185 (+) 729 WP_000418692.1 GNAT family N-acetyltransferase -
  AABA14_RS03730 (TKY123642_07200) - 720227..721096 (+) 870 WP_001245823.1 putative PEP-binding protein -
  AABA14_RS03735 (TKY123642_07210) - 721071..721511 (+) 441 WP_001813258.1 ASCH domain-containing protein -
  AABA14_RS03740 (TKY123642_07220) - 721634..724180 (+) 2547 WP_338168474.1 M1 family metallopeptidase -
  AABA14_RS03745 (TKY123642_07230) ciaR 724289..724963 (+) 675 WP_042516090.1 two-component system response regulator CiaR Regulator
  AABA14_RS03750 (TKY123642_07240) ciaH 724953..726287 (+) 1335 WP_000491790.1 two-component system sensor histidine kinase CiaH Regulator
  AABA14_RS03755 (TKY123642_07250) - 726321..726608 (-) 288 WP_042516091.1 DUF3270 domain-containing protein -
  AABA14_RS03760 (TKY123642_07260) - 726748..727677 (+) 930 WP_000411853.1 peptidase U32 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25480.32 Da        Isoelectric Point: 4.3283

>NTDB_id=106269 AABA14_RS03745 WP_042516090.1 724289..724963(+) (ciaR) [Streptococcus pneumoniae strain Sep2]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPIELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=106269 AABA14_RS03745 WP_042516090.1 724289..724963(+) (ciaR) [Streptococcus pneumoniae strain Sep2]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
TATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGTGTCTATGACTTGATTTTGCTGGATTTGATGT
TGCCAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGGATTCAGGCCCTTCTCAAACGTTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGG
TTAATTTATCAACCAATACCGTTAAAGTTGAAGATACTCCTATCGAATTGCTGGGGAAAGAGTTCGACTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAAACTTTGC
GTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

99.554

100

0.996
  ciaR Streptococcus pneumoniae D39

99.554

100

0.996
  ciaR Streptococcus pneumoniae R6

99.554

100

0.996
  ciaR Streptococcus pneumoniae TIGR4

99.554

100

0.996
  ciaR Streptococcus mutans UA159

87.946

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.168

100

0.375
  vicR Streptococcus mutans UA159

35.193

100

0.366

Multiple sequence alignment