Detailed information NTG0106193

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: AAA996_RS04790
• Genome accession: NZ_AP028606
• Coordinates: 938172..938876 (+)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain Sep1
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 933172..943876

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAA996_RS04770 (TKY121773_09500)	coaC	933461..934012 (-)	552	WP_001284130.1	phosphopantothenoylcysteine decarboxylase	-
AAA996_RS04775 (TKY121773_09510)	coaB	934024..934713 (-)	690	WP_000699531.1	phosphopantothenate--cysteine ligase	-
AAA996_RS04780 (TKY121773_09520)	-	934943..936613 (+)	1671	WP_000845295.1	formate--tetrahydrofolate ligase	-
AAA996_RS04785 (TKY121773_09530)	mutY	936942..938117 (+)	1176	WP_000886144.1	A/G-specific adenine glycosylase	-
AAA996_RS04790 (TKY121773_09540)	micA	938172..938876 (+)	705	WP_000722076.1	response regulator YycF	Regulator
AAA996_RS04795 (TKY121773_09550)	micB	938869..940218 (+)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
AAA996_RS04800 (TKY121773_09560)	vicX	940220..941029 (+)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
AAA996_RS04805 (TKY121773_09570)	-	941120..941362 (+)	243	WP_000208080.1	DUF6290 family protein	-
AAA996_RS04810 (TKY121773_09580)	-	941364..941618 (+)	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	-
AAA996_RS04815 (TKY121773_09590)	-	941665..942408 (+)	744	WP_000731133.1	potassium channel family protein	-
AAA996_RS04820 (TKY121773_09600)	-	942697..943683 (-)	987	WP_000204731.1	L-lactate dehydrogenase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=106193 AAA996_RS04790 WP_000722076.1 938172..938876(+) (micA) [Streptococcus pneumoniae strain Sep1]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=106193 AAA996_RS04790 WP_000722076.1 938172..938876(+) (micA) [Streptococcus pneumoniae strain Sep1]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38