Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   AAA985_RS02890 Genome accession   NZ_AP028603
Coordinates   539026..539763 (+) Length   245 a.a.
NCBI ID   WP_001219143.1    Uniprot ID   A0A0U0IWP6
Organism   Streptococcus pneumoniae strain Pne2     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 519869..548307 539026..539763 within 0


Gene organization within MGE regions


Location: 519869..548307
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAA985_RS02800 (TKY181970_05470) - 519869..521149 (+) 1281 WP_001220758.1 restriction endonuclease subunit S -
  AAA985_RS02805 (TKY181970_05480) psrA 521206..522003 (+) 798 WP_000651177.1 tyrosine-type DNA invertase PsrA -
  AAA985_RS02810 (TKY181970_05490) - 522014..522619 (+) 606 WP_001813510.1 restriction endonuclease subunit S -
  AAA985_RS02815 - 522567..524162 (-) 1596 Protein_554 restriction endonuclease subunit S -
  AAA985_RS02820 (TKY181970_05520) - 524162..525625 (-) 1464 WP_000029036.1 class I SAM-dependent DNA methyltransferase -
  AAA985_RS02825 (TKY181970_05530) - 525638..527971 (-) 2334 WP_000229105.1 DEAD/DEAH box helicase family protein -
  AAA985_RS02830 (TKY181970_05540) - 528579..529088 (+) 510 Protein_557 DUF2812 domain-containing protein -
  AAA985_RS02835 (TKY181970_05550) hrcA 529252..530286 (+) 1035 WP_000255781.1 heat-inducible transcriptional repressor HrcA -
  AAA985_RS02840 (TKY181970_05560) grpE 530313..530837 (+) 525 WP_000046035.1 nucleotide exchange factor GrpE -
  AAA985_RS02845 (TKY181970_05570) dnaK 531317..533140 (+) 1824 WP_000034662.1 molecular chaperone DnaK -
  AAA985_RS02850 (TKY181970_05580) - 533142..533498 (+) 357 WP_000114422.1 hypothetical protein -
  AAA985_RS02855 (TKY181970_05590) dnaJ 533900..535036 (+) 1137 WP_001066301.1 molecular chaperone DnaJ -
  AAA985_RS02860 (TKY181970_05600) - 535358..535645 (-) 288 WP_000777760.1 hypothetical protein -
  AAA985_RS02865 (TKY181970_05610) - 535655..536065 (-) 411 WP_001278301.1 HIT family protein -
  AAA985_RS02870 (TKY181970_05620) pptA 536133..536864 (+) 732 WP_000889919.1 ABC transporter ATP-binding protein Regulator
  AAA985_RS02875 (TKY181970_05630) - 536861..537910 (+) 1050 WP_000653773.1 ABC transporter permease -
  AAA985_RS02880 (TKY181970_05640) - 538078..538407 (-) 330 WP_000132572.1 hypothetical protein -
  AAA985_RS02885 (TKY181970_05650) - 538683..539021 (+) 339 WP_000682126.1 LytTR family DNA-binding domain-containing protein -
  AAA985_RS02890 (TKY181970_05660) comE/blpR 539026..539763 (+) 738 WP_001219143.1 response regulator transcription factor Regulator
  AAA985_RS02895 (TKY181970_05670) - 539777..541117 (+) 1341 WP_001028651.1 sensor histidine kinase -
  AAA985_RS02900 (TKY181970_05680) blpC 541162..541317 (-) 156 WP_000358814.1 quorum-sensing system pheromone BlpC -
  AAA985_RS02905 (TKY181970_05690) - 541374..542735 (-) 1362 WP_001069081.1 bacteriocin secretion accessory protein -
  AAA985_RS02910 (TKY181970_05700) - 542746..544793 (-) 2048 Protein_573 peptide cleavage/export ABC transporter -
  AAA985_RS02915 (TKY181970_05720) blpU 545074..545304 (+) 231 WP_001093268.1 bacteriocin-like peptide BlpU -
  AAA985_RS02920 - 545307..545426 (+) 120 WP_000346298.1 PncF family bacteriocin immunity protein -
  AAA985_RS02925 (TKY181970_05730) - 545723..545887 (+) 165 WP_000727118.1 hypothetical protein -
  AAA985_RS02930 (TKY181970_05740) - 545884..546288 (+) 405 WP_000846944.1 hypothetical protein -
  AAA985_RS02935 - 546486..547291 (+) 806 Protein_578 IS5 family transposase -
  AAA985_RS02940 (TKY181970_05770) blpM 547441..547695 (+) 255 WP_000379879.1 two-peptide bacteriocin subunit BlpM -
  AAA985_RS02945 (TKY181970_05780) blpN 547711..547914 (+) 204 WP_001099492.1 two-peptide bacteriocin subunit BlpN -
  AAA985_RS02950 (TKY181970_05790) cipB 548158..548307 (+) 150 WP_001813641.1 bacteriocin-like peptide BlpO Regulator

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28812.93 Da        Isoelectric Point: 6.2366

>NTDB_id=105950 AAA985_RS02890 WP_001219143.1 539026..539763(+) (comE/blpR) [Streptococcus pneumoniae strain Pne2]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=105950 AAA985_RS02890 WP_001219143.1 539026..539763(+) (comE/blpR) [Streptococcus pneumoniae strain Pne2]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGATCGAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCTCGTCTTTTGCAGTGCCATCGCTCCTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGAGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0U0IWP6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.43

98.776

0.38
  comE Streptococcus infantis strain Atu-4

36.179

100

0.363

Multiple sequence alignment