Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   DK42_RS00980 Genome accession   NZ_CP007571
Coordinates   156407..157162 (+) Length   251 a.a.
NCBI ID   WP_000425371.1    Uniprot ID   Q8E259
Organism   Streptococcus agalactiae strain GBS2-NM     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 151407..162162
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK42_RS00965 (DK42_00970) - 151833..153383 (-) 1551 WP_000722378.1 ABC transporter substrate-binding protein/permease -
  DK42_RS00970 (DK42_00975) - 153519..155402 (+) 1884 WP_000710505.1 DUF2207 domain-containing protein -
  DK42_RS00975 (DK42_00980) - 155448..156287 (+) 840 WP_000905327.1 undecaprenyl-diphosphate phosphatase -
  DK42_RS00980 (DK42_00985) mecA 156407..157162 (+) 756 WP_000425371.1 adaptor protein MecA Regulator
  DK42_RS00985 (DK42_00990) - 157164..158324 (+) 1161 WP_000612112.1 MraY family glycosyltransferase -
  DK42_RS00990 (DK42_00995) ltrA 158900..160177 (+) 1278 WP_001292556.1 group II intron reverse transcriptase/maturase -
  DK42_RS00995 (DK42_01000) - 160227..161639 (-) 1413 WP_017771557.1 IS1182 family transposase -

Sequence

Protein


Download         Length: 251 a.a.        Molecular weight: 29054.91 Da        Isoelectric Point: 4.2155

>NTDB_id=105877 DK42_RS00980 WP_000425371.1 156407..157162(+) (mecA) [Streptococcus agalactiae strain GBS2-NM]
MEMKQISETTLKITISMEDLEDRGMELKDFLIPQEKTEEFFYSVMDELDLPENFKNSGMLSFRVTPKKDRIDVFVTKSEL
SKDLNLEELADLGDISKMSPEDFFKTLEQSMLEKGDTDAHAKLAEIENMMDKATQEVVEENVSEEQPEKEVETIGYVHYV
FDFDNIEAVVRFSQTIDFPIEASELYKNGKGYHMTILLDLENQPSYFANLMYARMLEHANVGTKTRAYLKEHSIQLIHDD
AISKLQMIEMG

Nucleotide


Download         Length: 756 bp        

>NTDB_id=105877 DK42_RS00980 WP_000425371.1 156407..157162(+) (mecA) [Streptococcus agalactiae strain GBS2-NM]
ATGGAAATGAAACAAATCAGTGAAACAACACTGAAAATTACAATTAGTATGGAAGATTTAGAAGATCGTGGTATGGAGCT
GAAAGATTTCCTAATCCCTCAGGAGAAGACTGAGGAATTTTTCTATTCTGTCATGGATGAATTAGACTTGCCAGAAAACT
TTAAAAATAGTGGTATGTTAAGTTTTCGAGTAACACCTAAAAAAGATCGCATTGATGTTTTTGTTACAAAGTCTGAATTA
AGTAAAGATTTAAATTTAGAAGAATTAGCAGATTTGGGTGACATTTCAAAAATGTCTCCAGAAGACTTTTTTAAAACCTT
GGAACAATCGATGTTGGAAAAAGGGGATACGGATGCTCATGCCAAATTAGCAGAAATTGAAAATATGATGGATAAAGCAA
CTCAAGAAGTAGTTGAGGAAAATGTTTCTGAAGAACAACCTGAAAAGGAAGTAGAAACGATTGGATATGTTCACTATGTC
TTTGATTTTGATAATATTGAAGCTGTAGTTCGATTTTCACAAACGATTGATTTTCCAATAGAAGCTTCTGAACTCTATAA
AAATGGTAAAGGCTATCATATGACAATTTTGCTAGACTTGGAAAACCAACCAAGCTACTTTGCTAATTTGATGTATGCTC
GAATGCTTGAACATGCTAATGTGGGCACAAAAACACGAGCTTACTTGAAAGAGCATAGTATTCAATTGATTCATGATGAT
GCTATTTCAAAATTACAAATGATTGAGATGGGATAA

Domains

Predicted by InterProScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-245)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8E259

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

67.742

98.805

0.669
  mecA Streptococcus thermophilus LMD-9

60.159

100

0.602
  mecA Streptococcus thermophilus LMG 18311

59.363

100

0.594
  mecA Streptococcus pneumoniae Rx1

46.614

100

0.466
  mecA Streptococcus pneumoniae D39

46.614

100

0.466
  mecA Streptococcus pneumoniae R6

46.614

100

0.466
  mecA Streptococcus pneumoniae TIGR4

46.614

100

0.466

Multiple sequence alignment