Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   AAA982_RS10615 Genome accession   NZ_AP028601
Coordinates   2052539..2053720 (+) Length   393 a.a.
NCBI ID   WP_000681598.1    Uniprot ID   A0A0B7M448
Organism   Streptococcus pneumoniae strain PF1     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 2047539..2058720
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAA982_RS10575 (TKY113292_20420) - 2048590..2049132 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  AAA982_RS10590 (TKY113292_20430) comE 2049375..2050127 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  AAA982_RS10595 (TKY113292_20440) comD/comD1 2050124..2051449 (-) 1326 WP_000362880.1 competence system sensor histidine kinase ComD Regulator
  AAA982_RS10600 (TKY113292_20450) comC/comC1 2051470..2051595 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  AAA982_RS10610 (TKY113292_20460) rlmH 2051877..2052356 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  AAA982_RS10615 (TKY113292_20470) htrA 2052539..2053720 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  AAA982_RS10620 (TKY113292_20480) spo0J 2053778..2054536 (+) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41827.69 Da        Isoelectric Point: 6.8902

>NTDB_id=105857 AAA982_RS10615 WP_000681598.1 2052539..2053720(+) (htrA) [Streptococcus pneumoniae strain PF1]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=105857 AAA982_RS10615 WP_000681598.1 2052539..2053720(+) (htrA) [Streptococcus pneumoniae strain PF1]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAATAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGGGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTAAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M448

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

99.746

100

0.997
  htrA Streptococcus pneumoniae D39

99.746

100

0.997
  htrA Streptococcus pneumoniae R6

99.746

100

0.997
  htrA Streptococcus pneumoniae TIGR4

99.746

100

0.997
  htrA Streptococcus mitis NCTC 12261

97.455

100

0.975
  htrA Streptococcus gordonii str. Challis substr. CH1

66.667

100

0.672
  htrA Streptococcus mutans UA159

54.822

100

0.55

Multiple sequence alignment