Detailed information NTG0105797

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: AAA982_RS02660
• Genome accession: NZ_AP028601
• Coordinates: 515378..515965 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain PF1
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 510378..520965

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAA982_RS02640 (TKY113292_05150)	-	510840..512180 (+)	1341	WP_001017646.1	sensor histidine kinase	-
AAA982_RS02645 (TKY113292_05160)	blpC	512251..512379 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
AAA982_RS02650 (TKY113292_05170)	-	512436..513797 (-)	1362	Protein_521	bacteriocin secretion accessory protein	-
AAA982_RS02655 (TKY113292_05190)	comA/nlmT	513808..515484 (-)	1677	WP_306423909.1	peptide cleavage/export ABC transporter	Regulator
AAA982_RS02660 (TKY113292_05200)	comA/nlmT	515378..515965 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
AAA982_RS02665 (TKY113292_05220)	-	516239..516442 (+)	204	WP_001093272.1	bacteriocin class II family protein	-
AAA982_RS02670 (TKY113292_05230)	-	516760..516963 (+)	204	WP_000411016.1	hypothetical protein	-
AAA982_RS02675	-	517966..518770 (+)	805	Protein_526	IS5 family transposase	-
AAA982_RS02680 (TKY113292_05270)	blpM	518920..519181 (+)	262	Protein_527	two-peptide bacteriocin subunit BlpM	-
AAA982_RS02685 (TKY113292_05280)	blpN	519197..519400 (+)	204	WP_001099492.1	two-peptide bacteriocin subunit BlpN	-
AAA982_RS02690 (TKY113292_05290)	-	519644..519877 (+)	234	WP_338168332.1	ComC/BlpC family peptide pheromone/bacteriocin	-
AAA982_RS02695 (TKY113292_05300)	-	519909..520598 (+)	690	WP_000760541.1	CPBP family intramembrane glutamic endopeptidase	-
AAA982_RS02700 (TKY113292_05310)	blpZ	520640..520888 (+)	249	WP_000276499.1	immunity protein BlpZ	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=105797 AAA982_RS02660 WP_000205166.1 515378..515965(-) (comA/nlmT) [Streptococcus pneumoniae strain PF1]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=105797 AAA982_RS02660 WP_000205166.1 515378..515965(-) (comA/nlmT) [Streptococcus pneumoniae strain PF1]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497