Detailed information NTG0105795

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: AAA982_RS02635
• Genome accession: NZ_AP028601
• Coordinates: 510089..510826 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain PF1
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 505089..515826

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAA982_RS02600 (TKY113292_05070)	-	505975..506259 (-)	285	WP_050150649.1	hypothetical protein	-
AAA982_RS02605 (TKY113292_05080)	-	506421..506708 (-)	288	WP_317649295.1	hypothetical protein	-
AAA982_RS02610 (TKY113292_05090)	-	506718..507128 (-)	411	WP_001278301.1	HIT family protein	-
AAA982_RS02615 (TKY113292_05100)	pptA	507196..507927 (+)	732	WP_000889956.1	ABC transporter ATP-binding protein	Regulator
AAA982_RS02620 (TKY113292_05110)	-	507924..508973 (+)	1050	WP_317641679.1	ABC transporter permease	-
AAA982_RS02625 (TKY113292_05120)	-	509141..509470 (-)	330	WP_000132567.1	hypothetical protein	-
AAA982_RS02630 (TKY113292_05130)	-	509746..510084 (+)	339	WP_000682120.1	LytTR family DNA-binding domain-containing protein	-
AAA982_RS02635 (TKY113292_05140)	comE/blpR	510089..510826 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
AAA982_RS02640 (TKY113292_05150)	-	510840..512180 (+)	1341	WP_001017646.1	sensor histidine kinase	-
AAA982_RS02645 (TKY113292_05160)	blpC	512251..512379 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
AAA982_RS02650 (TKY113292_05170)	-	512436..513797 (-)	1362	Protein_521	bacteriocin secretion accessory protein	-
AAA982_RS02655 (TKY113292_05190)	comA/nlmT	513808..515484 (-)	1677	WP_306423909.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=105795 AAA982_RS02635 WP_001219120.1 510089..510826(+) (comE/blpR) [Streptococcus pneumoniae strain PF1]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=105795 AAA982_RS02635 WP_001219120.1 510089..510826(+) (comE/blpR) [Streptococcus pneumoniae strain PF1]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363