Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   ACE8TD_RS11115 Genome accession   NZ_CP170116
Coordinates   2350433..2351719 (+) Length   428 a.a.
NCBI ID   WP_010737045.1    Uniprot ID   A0A2A4DST9
Organism   Enterococcus hirae strain 323p     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2316880..2357321 2350433..2351719 within 0


Gene organization within MGE regions


Location: 2316880..2357321
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACE8TD_RS10950 (ACE8TD_10950) - 2317219..2318163 (-) 945 WP_002377415.1 LCP family protein -
  ACE8TD_RS10955 (ACE8TD_10955) - 2318204..2318983 (-) 780 WP_088745830.1 hypothetical protein -
  ACE8TD_RS10960 (ACE8TD_10960) - 2319320..2320168 (-) 849 WP_395107394.1 IS982 family transposase -
  ACE8TD_RS10965 (ACE8TD_10965) - 2320231..2321139 (-) 909 WP_002332708.1 IS982-like element ISEfm1 family transposase -
  ACE8TD_RS10970 (ACE8TD_10970) - 2321808..2322950 (-) 1143 WP_010706266.1 glycosyltransferase -
  ACE8TD_RS10975 (ACE8TD_10975) - 2323029..2323173 (-) 145 Protein_2145 DUF536 domain-containing protein -
  ACE8TD_RS10980 (ACE8TD_10980) - 2323178..2323351 (-) 174 Protein_2146 replication initiation protein -
  ACE8TD_RS10985 (ACE8TD_10985) - 2323411..2324319 (-) 909 WP_002332708.1 IS982-like element ISEfm1 family transposase -
  ACE8TD_RS10990 (ACE8TD_10990) - 2324735..2326027 (-) 1293 WP_395107396.1 guanosine 5'-monophosphate oxidoreductase -
  ACE8TD_RS10995 (ACE8TD_10995) - 2326002..2327774 (-) 1773 WP_269407089.1 McrB family protein -
  ACE8TD_RS11000 (ACE8TD_11000) - 2327889..2331038 (-) 3150 WP_395107399.1 type I restriction endonuclease subunit R -
  ACE8TD_RS11005 (ACE8TD_11005) - 2331051..2332256 (-) 1206 WP_395107401.1 restriction endonuclease subunit S -
  ACE8TD_RS11010 (ACE8TD_11010) - 2332246..2333841 (-) 1596 WP_071243153.1 type I restriction-modification system subunit M -
  ACE8TD_RS11015 (ACE8TD_11015) - 2334024..2334353 (-) 330 Protein_2153 recombinase family protein -
  ACE8TD_RS11020 (ACE8TD_11020) - 2334371..2335324 (-) 954 WP_024265257.1 IS30 family transposase -
  ACE8TD_RS11025 (ACE8TD_11025) - 2335573..2336661 (-) 1089 WP_395107404.1 hypothetical protein -
  ACE8TD_RS11030 (ACE8TD_11030) - 2336904..2338541 (-) 1638 WP_395107406.1 recombinase family protein -
  ACE8TD_RS11035 (ACE8TD_11035) - 2338545..2339918 (-) 1374 WP_207431085.1 recombinase family protein -
  ACE8TD_RS11040 (ACE8TD_11040) - 2340185..2340451 (-) 267 WP_002340115.1 hypothetical protein -
  ACE8TD_RS11045 (ACE8TD_11045) - 2340426..2340590 (-) 165 WP_002340116.1 hypothetical protein -
  ACE8TD_RS11050 (ACE8TD_11050) - 2340634..2341467 (-) 834 WP_086309784.1 replication initiation factor domain-containing protein -
  ACE8TD_RS11055 (ACE8TD_11055) - 2341638..2342804 (+) 1167 WP_249456192.1 hypothetical protein -
  ACE8TD_RS11060 (ACE8TD_11060) - 2343318..2343680 (-) 363 WP_194178083.1 DUF4180 domain-containing protein -
  ACE8TD_RS11065 (ACE8TD_11065) - 2343691..2344461 (-) 771 WP_096709896.1 alpha/beta hydrolase -
  ACE8TD_RS11075 (ACE8TD_11075) - 2346007..2346288 (-) 282 Protein_2165 hypothetical protein -
  ACE8TD_RS11080 (ACE8TD_11080) - 2346363..2346659 (-) 297 WP_029485635.1 hypothetical protein -
  ACE8TD_RS11085 (ACE8TD_11085) - 2346652..2346944 (-) 293 Protein_2167 Mor transcription activator family protein -
  ACE8TD_RS11090 (ACE8TD_11090) - 2347090..2347641 (-) 552 WP_002312616.1 DUF1643 domain-containing protein -
  ACE8TD_RS11095 (ACE8TD_11095) - 2347815..2348114 (-) 300 WP_002312614.1 hypothetical protein -
  ACE8TD_RS11100 (ACE8TD_11100) - 2348141..2348449 (-) 309 WP_002317115.1 DUF960 domain-containing protein -
  ACE8TD_RS11105 (ACE8TD_11105) - 2348603..2349451 (-) 849 WP_002331982.1 hypothetical protein -
  ACE8TD_RS11110 (ACE8TD_11110) rlmH 2349501..2349980 (-) 480 WP_002317110.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ACE8TD_RS11115 (ACE8TD_11115) htrA 2350433..2351719 (+) 1287 WP_010737045.1 S1C family serine protease Regulator
  ACE8TD_RS11120 (ACE8TD_11120) ytpR 2351777..2352382 (-) 606 WP_010737044.1 YtpR family tRNA-binding protein -
  ACE8TD_RS11125 (ACE8TD_11125) - 2352691..2353158 (-) 468 WP_002317107.1 universal stress protein -
  ACE8TD_RS11130 (ACE8TD_11130) - 2353188..2353508 (-) 321 WP_010737043.1 thioredoxin family protein -
  ACE8TD_RS11135 (ACE8TD_11135) pepA 2354045..2355124 (-) 1080 WP_010720947.1 glutamyl aminopeptidase -
  ACE8TD_RS11140 (ACE8TD_11140) - 2355323..2355676 (+) 354 WP_002317104.1 PepSY domain-containing protein -
  ACE8TD_RS11145 (ACE8TD_11145) - 2355848..2356804 (+) 957 WP_002317103.1 glycosyltransferase family 2 protein -

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44581.68 Da        Isoelectric Point: 4.7976

>NTDB_id=1055178 ACE8TD_RS11115 WP_010737045.1 2350433..2351719(+) (htrA) [Enterococcus hirae strain 323p]
MERKDVTPKMKKNNGIWRKLGLGLVGGIIGGLVTAGIFYAVMGSGNAASNSGGHQNSAGETVVENVKVNVDSDITNAVDK
VQDAVVSVINLQSQNQGTNGFGQLFGQQQQESSDDSNLEASSEGSGVIYKKSGNSAYIVTNNHVVEGQQGLEVLLKDGTK
VKAELVGTDAYSDLAVLKISADKVNKVASFGDSNSLKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNQTVN
INAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSASSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITM
VDLSAVSTQQQEQILKIPESVTNGVIVTSVQPATPAEKAGLKQYDVITKIDDTDVSSGVELQSVLYQKKVGDSVKVTYYR
GKEKKTTTIQLTIDQSALKQSQSENSGN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=1055178 ACE8TD_RS11115 WP_010737045.1 2350433..2351719(+) (htrA) [Enterococcus hirae strain 323p]
ATGGAGAGAAAAGATGTGACACCAAAAATGAAAAAGAATAATGGAATCTGGCGTAAGCTGGGTCTAGGCTTAGTCGGTGG
AATTATTGGGGGCTTGGTAACGGCTGGTATTTTTTATGCTGTCATGGGTTCTGGAAACGCAGCGTCAAATTCGGGTGGTC
ATCAAAATTCAGCGGGCGAAACTGTCGTTGAGAATGTCAAAGTCAATGTCGATTCAGATATTACGAATGCGGTCGATAAA
GTCCAAGATGCGGTGGTATCTGTTATCAATCTTCAAAGCCAAAATCAAGGGACCAACGGCTTTGGGCAACTGTTTGGCCA
ACAACAACAAGAAAGTTCTGATGATAGCAACCTAGAGGCTTCTAGTGAAGGTAGTGGTGTCATCTACAAAAAAAGTGGTA
ATTCCGCTTATATCGTAACGAATAATCACGTAGTGGAAGGCCAACAAGGATTAGAAGTTTTATTAAAAGATGGAACAAAA
GTCAAAGCTGAATTAGTCGGGACGGATGCTTATTCTGACTTAGCCGTTTTGAAAATCAGTGCAGATAAAGTGAACAAAGT
TGCTTCATTTGGTGACTCTAATTCATTGAAAGTAGGTGAACCGGCGATCGCAATTGGTTCTCCTTTAGGTTCTGAATATG
CCAACTCTGTGACTTCGGGGATTATCTCTTCATTGAATCGCCAAGTAACCAGCACGAACGAGTCAAATCAAACGGTCAAT
ATCAATGCGATCCAAACAGATGCTGCGATCAACCCTGGTAATTCTGGTGGTCCATTAGTTAATATCGAAGGTCAAGTGAT
CGGGATCAATTCAAGTAAAATTGCAAGTACTTCTGCTTCTTCATCAGGTGTAAGCGTGGAAGGAATGGGCTTTGCGATCC
CAAGTAACGATGTAGTAAATATTATCAACCAACTTGAAAAAGATGGAAAAGTAACCCGTCCTGCTCTAGGGATCACAATG
GTTGACCTTTCAGCCGTTTCAACCCAACAACAAGAACAAATCTTGAAAATTCCTGAATCTGTGACAAATGGTGTGATTGT
TACCAGCGTTCAACCGGCGACACCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTCATTACAAAAATCGATGATACTG
ATGTTTCTTCTGGTGTAGAATTACAATCTGTCTTGTATCAGAAAAAAGTCGGCGATTCAGTGAAGGTCACTTACTATCGC
GGAAAAGAAAAGAAAACAACAACAATTCAATTAACAATTGATCAATCCGCATTAAAACAAAGCCAATCAGAGAACTCTGG
TAACTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(124-269)

PDZ domain (PDZ_2)

(314-411)

Peptidase family M50 (Peptidase_M50)

(12-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2A4DST9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

54.545

92.523

0.505
  htrA Streptococcus gordonii str. Challis substr. CH1

53.35

94.159

0.502
  htrA Streptococcus pneumoniae Rx1

58.457

78.738

0.46
  htrA Streptococcus pneumoniae D39

58.457

78.738

0.46
  htrA Streptococcus pneumoniae R6

58.457

78.738

0.46
  htrA Streptococcus pneumoniae TIGR4

58.457

78.738

0.46
  htrA Streptococcus mitis NCTC 12261

57.567

78.738

0.453

Multiple sequence alignment