Detailed information NTG1050500

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: ACEY2B_RS11920
• Genome accession: NZ_CP169315
• Coordinates: 2408311..2410458 (-)
• Length: 715 a.a.
• NCBI ID: WP_058219490.1
• Uniprot ID: A0A0V8CYE5
• Organism: Lactococcus lactis strain IFLLLBEK1
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 2403311..2415458

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACEY2B_RS11895 (ACEY2B_11895)	rpmF	2405075..2405248 (+)	174	WP_010905107.1	50S ribosomal protein L32	-
ACEY2B_RS11900 (ACEY2B_11900)	rpmG	2405278..2405427 (+)	150	WP_003132258.1	50S ribosomal protein L33	-
ACEY2B_RS11905 (ACEY2B_11905)	-	2405741..2406397 (-)	657	WP_374788084.1	lysostaphin resistance A-like protein	-
ACEY2B_RS11910 (ACEY2B_11910)	-	2406634..2406771 (-)	138	WP_081041351.1	lactococcin family bacteriocin	-
ACEY2B_RS11915 (ACEY2B_11915)	-	2406875..2408296 (-)	1422	WP_058218265.1	bacteriocin secretion accessory protein	-
ACEY2B_RS11920 (ACEY2B_11920)	comA	2408311..2410458 (-)	2148	WP_058219490.1	peptide cleavage/export ABC transporter	Regulator
ACEY2B_RS11925 (ACEY2B_11925)	-	2410726..2410878 (+)	153	WP_081041352.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
ACEY2B_RS11930 (ACEY2B_11930)	-	2410936..2411640 (+)	705	WP_058219491.1	CPBP family intramembrane glutamic endopeptidase	-
ACEY2B_RS11935 (ACEY2B_11935)	-	2411663..2412118 (+)	456	WP_058217941.1	hypothetical protein	-
ACEY2B_RS11940 (ACEY2B_11940)	-	2412200..2412334 (-)	135	WP_268766086.1	hypothetical protein	-
ACEY2B_RS11945 (ACEY2B_11945)	-	2412511..2413101 (-)	591	WP_374788085.1	flavin reductase family protein	-
ACEY2B_RS11950 (ACEY2B_11950)	-	2413112..2414281 (-)	1170	WP_374788086.1	ring-cleaving dioxygenase	-
ACEY2B_RS11955 (ACEY2B_11955)	-	2414332..2414952 (-)	621	WP_374788087.1	alpha/beta hydrolase	-
ACEY2B_RS11960 (ACEY2B_11960)	-	2414983..2415180 (-)	198	WP_012896939.1	DUF4649 domain-containing protein	-

Sequence

Protein

• Length: 715 a.a.
• Molecular weight: 79864.46 Da
• Isoelectric Point: 8.6948

>NTDB_id=1050500 ACEY2B_RS11920 WP_058219490.1 2408311..2410458(-) (comA) [Lactococcus lactis strain IFLLLBEK1]
MKFKKKNYTQQVDEMDCGCAALSMILKSYGTEKSLASLRLLAGTTIEGTSALGIKKAGEGLGFAVQVLRADASLFEMKGV
PYPFIAHVIKNQKYPHYYVITGTNKNSVFIADPDPTVKMAKLSKEVFLSEWTGISLFLSPTPSYQPAKEKASSLLSFIPI
IARQKKVILNIVIASFIVTLINILGSYYLQSMIDSYIPNALMGTLGIISVGLLLTYIIQQVLEFAKTFLLNVLSQRLAID
VILSYIRHIFQLPMSFFSTRRTGEITSRFSDASSILDAIASTILSLFLDLTIVVMTGLILGLQNMQLFLLVLLAIPLYIV
VIIIFTPLFERQNHEVMQTNAILNSSIIEDINGIETIKALASEQERYQKIDYEFASYLKKAFTLQQSEAIQTVIKTTVQL
TLNVLILWFGATLVMHQKITLGQLITFNALLSYFTNPITNIINLQTKLQKARVANERLNEVYLVPSEFEEKKTELSLSHF
NLNMSEISYQYGFCRKVLSEIKLSIKENEKLTIVGMSGSGKSTLVKLLVNFFQPTSGTITLGGVDLQQFDKHQLRRLINY
LPQQPYIFTGSILDNLLLGTNENASQEEILKAVELAEIRVDIEQMQLGYQTELSSDASSLSGGQKQRIALARALLSPAKI
LILDEATSNLDMITEKKILKNLLALDKTIIFIAHRLSVAEMSHRIIVIEQGKVIESGSHSELLAQNGFYAQLYHN

Nucleotide

• Length: 2148 bp

>NTDB_id=1050500 ACEY2B_RS11920 WP_058219490.1 2408311..2410458(-) (comA) [Lactococcus lactis strain IFLLLBEK1]
ATGAAATTTAAAAAGAAAAATTATACCCAACAAGTGGATGAAATGGACTGTGGCTGTGCTGCTTTATCGATGATTTTAAA
GTCTTATGGCACAGAAAAGTCACTCGCTTCATTGCGTTTACTTGCTGGCACAACAATCGAAGGAACTTCCGCTTTAGGAA
TAAAAAAAGCAGGAGAAGGGCTAGGTTTTGCAGTTCAAGTACTAAGAGCAGACGCAAGCCTTTTTGAAATGAAGGGAGTC
CCTTATCCTTTTATCGCTCATGTCATTAAGAATCAAAAATATCCACACTACTATGTAATCACTGGTACAAATAAAAATTC
GGTATTCATTGCAGATCCTGACCCGACCGTTAAAATGGCAAAATTATCAAAAGAAGTTTTCTTATCGGAATGGACGGGCA
TTAGTTTATTTCTTTCACCTACACCATCTTATCAGCCCGCCAAAGAAAAAGCTTCCTCATTATTATCTTTTATCCCAATT
ATCGCCCGTCAAAAGAAAGTCATTCTCAATATTGTTATTGCCTCATTCATTGTAACGTTGATTAATATTCTAGGGTCTTA
CTACCTCCAGAGCATGATTGACAGTTATATTCCAAATGCTTTAATGGGAACTTTAGGGATTATCTCAGTAGGACTATTAT
TGACTTATATTATCCAACAAGTCTTAGAGTTTGCTAAGACTTTCTTACTGAATGTTCTTTCTCAAAGATTAGCTATTGAT
GTTATTCTTTCTTATATTAGACACATTTTCCAACTTCCGATGTCTTTCTTTTCGACTAGAAGAACAGGGGAAATTACCAG
TCGGTTTTCCGATGCCAGTTCTATTTTAGATGCTATTGCCTCAACGATTCTTTCGCTCTTTTTAGATTTGACGATTGTCG
TCATGACAGGACTAATTTTAGGTCTTCAAAATATGCAACTATTTCTTCTCGTTCTTTTGGCAATCCCACTTTATATTGTT
GTTATTATTATTTTTACTCCGCTTTTTGAACGACAAAATCATGAAGTTATGCAAACCAATGCCATCTTAAATTCCTCAAT
TATTGAAGATATTAATGGGATTGAAACCATCAAAGCGCTCGCCAGTGAACAAGAAAGATATCAAAAAATTGACTACGAAT
TTGCAAGTTATCTAAAAAAGGCTTTCACTTTACAACAGTCAGAAGCCATTCAGACGGTAATAAAAACAACAGTACAATTA
ACATTAAATGTCCTTATTTTATGGTTTGGTGCAACTTTAGTCATGCATCAAAAAATTACCCTCGGACAACTCATTACTTT
TAATGCCTTGCTTTCTTACTTTACAAATCCAATTACTAATATCATTAACCTTCAAACAAAACTCCAAAAGGCAAGGGTAG
CCAATGAACGATTAAATGAGGTCTATCTTGTACCCAGTGAATTTGAGGAAAAGAAAACAGAACTGTCCCTCTCACATTTT
AATTTAAACATGTCTGAGATTTCATATCAATATGGTTTTTGCAGAAAAGTCTTATCTGAGATAAAACTGTCTATTAAAGA
AAATGAAAAGTTGACCATTGTTGGTATGAGCGGTTCAGGGAAGAGTACTCTTGTTAAATTATTGGTCAACTTCTTTCAAC
CCACTTCTGGTACCATCACTTTAGGTGGAGTTGACCTTCAACAGTTTGATAAACACCAACTCCGACGATTAATCAACTAT
CTTCCACAACAACCTTATATTTTTACTGGTTCGATTTTAGATAATTTACTTCTAGGAACTAATGAGAATGCCTCACAAGA
AGAGATTCTTAAAGCGGTGGAATTAGCAGAAATCCGTGTAGACATTGAACAAATGCAGTTAGGCTATCAGACCGAACTTT
CAAGTGATGCAAGTAGTCTATCGGGAGGACAAAAACAACGAATTGCTTTAGCTCGTGCGCTCCTTTCTCCTGCCAAAATA
CTCATTTTAGATGAAGCTACCAGCAACCTAGATATGATTACTGAAAAGAAAATATTAAAAAATTTGTTGGCATTGGATAA
AACAATTATTTTCATTGCTCACCGCCTCTCTGTAGCGGAAATGAGCCATCGTATCATTGTCATTGAGCAAGGAAAAGTGA
TAGAAAGTGGTTCACATTCAGAACTGCTTGCTCAAAATGGCTTTTACGCACAACTTTACCATAACTAA

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (498-648)

• Peptidase C39 family (Peptidase_C39) (6-142)

• ABC transporter transmembrane region (ABC_membrane) (169-437)

3D structure

• AlphaFold DB: A0A0V8CYE5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus gordonii str. Challis substr. CH1	61.204	99.86	0.611
comA	Streptococcus mitis NCTC 12261	59.944	99.86	0.599
comA	Streptococcus mitis SK321	59.804	99.86	0.597
comA	Streptococcus pneumoniae R6	59.524	99.86	0.594
comA	Streptococcus pneumoniae Rx1	59.524	99.86	0.594
comA	Streptococcus pneumoniae D39	59.524	99.86	0.594
comA	Streptococcus pneumoniae TIGR4	59.244	99.86	0.592
comA/nlmT	Streptococcus mutans UA159	57.799	100	0.58