Detailed information NTG1044687

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: AB8O74_RS08785
• Genome accession: NZ_CP168648
• Coordinates: 1837296..1839488 (-)
• Length: 730 a.a.
• NCBI ID: WP_003585566.1
• Uniprot ID: A0A829GXH9
• Organism: Lacticaseibacillus paracasei strain MGL98
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1832296..1844488

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AB8O74_RS08755 (AB8O74_08755)	-	1832462..1832746 (-)	285	WP_003567331.1	bacteriocin immunity protein	-
AB8O74_RS08760 (AB8O74_08760)	-	1832939..1833235 (-)	297	WP_003596056.1	bacteriocin immunity protein	-
AB8O74_RS08765 (AB8O74_08765)	-	1833337..1834692 (-)	1356	WP_003567335.1	threonine/serine exporter ThrE family protein	-
AB8O74_RS08770 (AB8O74_08770)	-	1834998..1835309 (-)	312	WP_003580849.1	hypothetical protein	-
AB8O74_RS08775 (AB8O74_08775)	-	1835382..1835732 (-)	351	WP_003567340.1	hypothetical protein	-
AB8O74_RS08780 (AB8O74_08780)	-	1835906..1837285 (-)	1380	WP_003585563.1	bacteriocin secretion accessory protein	-
AB8O74_RS08785 (AB8O74_08785)	comA	1837296..1839488 (-)	2193	WP_003585566.1	peptide cleavage/export ABC transporter	Regulator
AB8O74_RS08790 (AB8O74_08790)	-	1839954..1840091 (-)	138	WP_003571414.1	bacteriocin-like peptide, LSEI_2386 family	-
AB8O74_RS08795 (AB8O74_08795)	-	1840281..1841579 (+)	1299	WP_003580853.1	GHKL domain-containing protein	-
AB8O74_RS08800 (AB8O74_08800)	-	1841584..1842390 (+)	807	WP_003567351.1	LytTR family DNA-binding domain-containing protein	-
AB8O74_RS08805 (AB8O74_08805)	-	1842752..1842949 (-)	198	WP_016383118.1	hypothetical protein	-
AB8O74_RS08810 (AB8O74_08810)	-	1843496..1843765 (+)	270	WP_016369462.1	hypothetical protein	-
AB8O74_RS08815 (AB8O74_08815)	-	1844009..1844182 (-)	174	WP_013246049.1	bacteriocin	-
AB8O74_RS08820 (AB8O74_08820)	-	1844221..1844394 (-)	174	WP_373443355.1	hypothetical protein	-

Sequence

Protein

• Length: 730 a.a.
• Molecular weight: 81282.51 Da
• Isoelectric Point: 7.0227

>NTDB_id=1044687 AB8O74_RS08785 WP_003585566.1 1837296..1839488(-) (comA) [Lacticaseibacillus paracasei strain MGL98]
MIKYNLKLGQAQYYKRYYTPQVDERDCGVAALNMLLQFNGSDYSLAHLRQLAKTDQEGTTALGIVRAAQALHFETKAVKA
DMTLFDLDDVPYPFLVHVLKRGELLHYYVVFKATKDHILIGDPDPSVAMTWLPKERFAKEWSGVAIFIAPEPQYQPRKED
KGSLFAFVPILARQKGIIANIIVAAVLITLISIVGSYFLQSIIDTYIPNGMRTTLGMIASGLILAYVLQSVLTYGQNFLM
AVLGQRLSIDVILGYVRHLYELPMSFFSTRRTGEIVSRFSDANKIIDALANTIMTLFLDIWIVLILGIVLGIQNTTLFLV
SLIAVPCYLVIVFAFQRPFNRLNQETMESNAILSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYTKADQL
QQAIKGLLKLVLNVVVLWIGASLVMANKMSLGQMLTFNALLAYFTNPLESIINLQPKLQMAKVANNRLNEVYLVESEFKE
QRSLNDRHLIDGAINVTDVSFKYGFGQDVLKQINLEIPENAKYTIVGMSGSGKSTLAKLLVGFYPVDTGKGKITFNGVPI
SDVDLTTLRQYIEYVPQDPFIFSGSVIENLTLGSRSNITEADIEAACSVAEIAGDISNLPQIWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGAIVEQGNHAELLAK
QGYYARLVSE

Nucleotide

• Length: 2193 bp

>NTDB_id=1044687 AB8O74_RS08785 WP_003585566.1 1837296..1839488(-) (comA) [Lacticaseibacillus paracasei strain MGL98]
ATGATCAAATACAACCTAAAGCTCGGCCAAGCACAGTATTACAAGCGTTACTACACGCCTCAGGTGGATGAGCGCGATTG
CGGGGTTGCGGCGCTTAATATGTTGCTGCAATTTAATGGCTCGGATTATTCGCTAGCGCATCTGCGACAGTTGGCGAAGA
CGGATCAGGAAGGGACGACGGCATTAGGGATTGTCCGCGCTGCTCAGGCGCTTCATTTTGAAACCAAGGCGGTCAAGGCG
GATATGACGCTGTTTGATCTTGATGATGTTCCTTATCCGTTTCTTGTCCATGTTTTGAAGCGTGGCGAGTTGCTTCATTA
TTATGTGGTGTTTAAGGCGACAAAGGATCATATCTTGATTGGCGATCCTGATCCATCAGTAGCGATGACCTGGCTTCCCA
AAGAGCGCTTTGCGAAGGAGTGGTCGGGGGTCGCTATTTTTATTGCGCCAGAACCGCAATATCAACCACGCAAAGAGGAC
AAAGGCAGTCTCTTTGCGTTTGTGCCGATACTAGCGCGACAAAAAGGGATCATTGCCAATATTATTGTCGCCGCTGTGTT
GATTACGTTGATTAGTATTGTCGGGTCTTATTTTCTTCAGTCGATTATTGATACTTATATTCCAAACGGGATGCGCACAA
CTTTGGGAATGATTGCCAGTGGTCTCATCCTTGCTTATGTCCTGCAGTCGGTTTTAACCTATGGGCAAAATTTTTTGATG
GCTGTTTTAGGACAGCGTTTGTCGATTGATGTCATTTTGGGTTACGTTAGGCATCTTTATGAATTACCGATGTCCTTCTT
TTCCACGCGTCGGACTGGGGAGATTGTATCGCGGTTTTCCGATGCTAATAAGATTATTGATGCGCTGGCAAACACAATTA
TGACCTTGTTTCTTGATATTTGGATTGTCTTAATTTTAGGGATCGTGTTAGGCATTCAAAACACCACCTTATTCTTGGTG
TCTTTAATTGCTGTGCCTTGTTATTTGGTGATTGTGTTCGCTTTTCAGCGGCCATTTAATCGACTGAATCAAGAGACGAT
GGAAAGCAATGCCATATTGAGTTCATCCATTATCGAGGATTTGAACGGGATTGAGACGATTAAATCACTGACCGGTGAGA
AAGTCAGTTATGAACGGGTTGACCGTGAATTCGTCACGTATTTGAAAAAGTCGTTCAATTATACAAAAGCTGATCAACTG
CAGCAGGCGATCAAGGGACTGCTGAAGTTGGTTTTGAATGTGGTCGTGCTGTGGATTGGTGCGAGTTTGGTGATGGCTAA
CAAGATGAGTCTAGGACAGATGCTGACGTTCAATGCGTTGTTGGCATATTTCACTAATCCGTTAGAAAGCATCATTAATT
TGCAACCAAAATTGCAAATGGCCAAAGTCGCGAATAACCGACTGAATGAAGTGTATTTGGTTGAATCGGAGTTTAAAGAA
CAGCGAAGTTTGAATGATCGGCATTTAATTGATGGCGCCATCAATGTTACCGATGTGTCCTTTAAGTATGGTTTTGGGCA
AGATGTTTTGAAACAAATCAACCTTGAAATCCCGGAGAATGCCAAATACACCATTGTCGGCATGAGCGGATCAGGAAAAT
CGACCTTAGCCAAGTTGCTAGTAGGTTTCTATCCAGTGGACACAGGCAAAGGGAAAATCACATTTAATGGTGTTCCCATC
AGTGATGTTGATCTGACAACGTTACGACAATATATCGAGTATGTACCACAAGATCCGTTTATTTTTTCTGGCTCAGTCAT
TGAAAACTTAACGTTGGGTAGCCGTTCGAATATCACTGAAGCCGATATTGAAGCTGCCTGTTCAGTGGCGGAAATTGCCG
GAGATATTTCGAATTTGCCGCAGATATGGCAGACCAAACTTTCTGAAAGCGGCAGTATTTTATCGGGTGGACAAAAGCAG
CGCCTAGCAATTGCCCGCGCGTTATTATCACCGGCAAAAGTGTTGATTTTTGATGAATCGACCAGCAGTTTAGATACGAT
CACCGAGCGAAAAATTGTTGATCGGTTGTTAGCGATGACTGATCGAACCATTATTTTTGTGGCTCATCGGCTCACTATTG
CTGCTAAAACGGAACAGATTGTGGTCATGGACCATGGTGCGATTGTTGAACAAGGAAATCATGCTGAGTTATTGGCCAAA
CAAGGCTATTATGCTCGGTTGGTAAGTGAGTGA

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (510-662)

• Peptidase C39 family (Peptidase_C39) (16-152)

• ABC transporter transmembrane region (ABC_membrane) (180-448)

3D structure

• AlphaFold DB: A0A829GXH9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	59.053	98.356	0.581
comA	Streptococcus pneumoniae Rx1	58.496	98.356	0.575
comA	Streptococcus pneumoniae D39	58.496	98.356	0.575
comA	Streptococcus pneumoniae R6	58.496	98.356	0.575
comA	Streptococcus mitis SK321	58.357	98.356	0.574
comA	Streptococcus pneumoniae TIGR4	58.078	98.356	0.571
comA	Streptococcus gordonii str. Challis substr. CH1	57.103	98.356	0.562
comA/nlmT	Streptococcus mutans UA159	54.986	98.904	0.544