Detailed information NTG1043727

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ACD268_RS08400
• Genome accession: NZ_CP168299
• Coordinates: 1641731..1642468 (-)
• Length: 245 a.a.
• NCBI ID: WP_050110750.1
• Uniprot ID: A0A822QGH1
• Organism: Streptococcus pneumoniae strain FC1
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1636731..1647468

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACD268_RS08380 (ACD268_08380)	comA/nlmT	1637105..1638748 (+)	1644	WP_078132631.1	peptide cleavage/export ABC transporter	Regulator
ACD268_RS08385 (ACD268_08385)	-	1638759..1640120 (+)	1362	WP_050238786.1	bacteriocin secretion accessory protein	-
ACD268_RS08390 (ACD268_08390)	blpC	1640177..1640332 (+)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
ACD268_RS08395 (ACD268_08395)	-	1640377..1641717 (-)	1341	WP_050110752.1	sensor histidine kinase	-
ACD268_RS08400 (ACD268_08400)	comE/blpR	1641731..1642468 (-)	738	WP_050110750.1	LytTR family DNA-binding domain-containing protein	Regulator
ACD268_RS08405 (ACD268_08405)	-	1642473..1642811 (-)	339	WP_050110747.1	LytTR family DNA-binding domain-containing protein	-
ACD268_RS08410 (ACD268_08410)	-	1643086..1643415 (+)	330	WP_000132575.1	hypothetical protein	-
ACD268_RS08415 (ACD268_08415)	-	1643583..1644632 (-)	1050	WP_373381814.1	ABC transporter permease	-
ACD268_RS08420 (ACD268_08420)	pptA	1644629..1645360 (-)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
ACD268_RS08425 (ACD268_08425)	-	1645428..1645838 (+)	411	WP_044814957.1	HIT family protein	-
ACD268_RS08430 (ACD268_08430)	-	1645848..1646135 (+)	288	WP_000777753.1	hypothetical protein	-
ACD268_RS08435 (ACD268_08435)	-	1646297..1646671 (+)	375	WP_373381815.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28796.97 Da
• Isoelectric Point: 6.3061

>NTDB_id=1043727 ACD268_RS08400 WP_050110750.1 1641731..1642468(-) (comE/blpR) [Streptococcus pneumoniae strain FC1]
MRIFVLEDDFSQQTRIETTIEKLLKAHYIIPSSFEVFGKPDQLLAEVHEKGTHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=1043727 ACD268_RS08400 WP_050110750.1 1641731..1642468(-) (comE/blpR) [Streptococcus pneumoniae strain FC1]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TTATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGACCCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCTCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGTTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A822QGH1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.038	96.735	0.416
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38