Detailed information NTG1043481

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ACD269_RS02510
• Genome accession: NZ_CP168260
• Coordinates: 486709..487446 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219137.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain FC2
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 481709..492446

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACD269_RS02475 (ACD269_02475)	-	482744..482983 (-)	240	WP_134743919.1	hypothetical protein	-
ACD269_RS02480 (ACD269_02480)	-	483145..483432 (-)	288	WP_000777760.1	hypothetical protein	-
ACD269_RS02485 (ACD269_02485)	-	483442..483852 (-)	411	WP_001278304.1	HIT family protein	-
ACD269_RS02490 (ACD269_02490)	pptA	483920..484651 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
ACD269_RS02495 (ACD269_02495)	-	484648..485697 (+)	1050	WP_000653750.1	ABC transporter permease	-
ACD269_RS02500 (ACD269_02500)	-	485760..486089 (-)	330	WP_000132584.1	hypothetical protein	-
ACD269_RS02505 (ACD269_02505)	-	486366..486704 (+)	339	WP_000682136.1	LytTR family DNA-binding domain-containing protein	-
ACD269_RS02510 (ACD269_02510)	comE/blpR	486709..487446 (+)	738	WP_001219137.1	LytTR family DNA-binding domain-containing protein	Regulator
ACD269_RS02515 (ACD269_02515)	-	487460..488800 (+)	1341	WP_001099895.1	sensor histidine kinase	-
ACD269_RS02520 (ACD269_02520)	blpC	488845..489000 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
ACD269_RS02525 (ACD269_02525)	-	489057..490418 (-)	1362	WP_050210660.1	bacteriocin secretion accessory protein	-
ACD269_RS02530 (ACD269_02530)	comA/nlmT	490429..492105 (-)	1677	WP_306423907.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28768.92 Da
• Isoelectric Point: 6.2366

>NTDB_id=1043481 ACD269_RS02510 WP_001219137.1 486709..487446(+) (comE/blpR) [Streptococcus pneumoniae strain FC2]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITLSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANGQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=1043481 ACD269_RS02510 WP_001219137.1 486709..487446(+) (comE/blpR) [Streptococcus pneumoniae strain FC2]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCTGAGTTCTTTTGAAGTTTTTGGTAAGCCAGATCAATTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCGTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATGGTCAAGACA
GTAAAAGTCTAGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCTCAATTCCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.441	100	0.539
comE/comE1	Streptococcus equinus JB1	43.038	96.735	0.416
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38