Detailed information    

insolico Bioinformatically predicted

Overview

Name   pilC   Type   Machinery gene
Locus tag   ACDK45_RS09370 Genome accession   NZ_CP167879
Coordinates   1875913..1877133 (-) Length   406 a.a.
NCBI ID   WP_011271971.1    Uniprot ID   Q4QNP6
Organism   Haemophilus influenzae strain NTHi52     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1870913..1882133
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACDK45_RS09330 (ACDK45_09330) - 1871785..1871991 (-) 207 WP_005631184.1 heavy-metal-associated domain-containing protein -
  ACDK45_RS09335 (ACDK45_09335) - 1872077..1872283 (-) 207 WP_012054944.1 heavy-metal-associated domain-containing protein -
  ACDK45_RS09340 (ACDK45_09340) - 1872369..1872575 (-) 207 WP_005648955.1 heavy-metal-associated domain-containing protein -
  ACDK45_RS09345 (ACDK45_09345) - 1872661..1872867 (-) 207 WP_012054944.1 heavy-metal-associated domain-containing protein -
  ACDK45_RS09350 (ACDK45_09350) cueR 1872944..1873330 (+) 387 WP_005663006.1 Cu(I)-responsive transcriptional regulator -
  ACDK45_RS09355 (ACDK45_09355) metJ 1873344..1873661 (-) 318 WP_005631186.1 met regulon transcriptional regulator MetJ -
  ACDK45_RS09360 (ACDK45_09360) rho 1873909..1875170 (+) 1262 Protein_1785 transcription termination factor Rho -
  ACDK45_RS09365 (ACDK45_09365) pilD 1875224..1875916 (-) 693 WP_038440789.1 A24 family peptidase Machinery gene
  ACDK45_RS09370 (ACDK45_09370) pilC 1875913..1877133 (-) 1221 WP_011271971.1 type II secretion system F family protein Machinery gene
  ACDK45_RS09375 (ACDK45_09375) pilB 1877130..1878524 (-) 1395 WP_044364868.1 GspE/PulE family protein Machinery gene
  ACDK45_RS09380 (ACDK45_09380) pilA 1878521..1878970 (-) 450 WP_044364865.1 prepilin-type N-terminal cleavage/methylation domain-containing protein Machinery gene
  ACDK45_RS09385 (ACDK45_09385) ampD 1879085..1879639 (+) 555 WP_044364862.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
  ACDK45_RS09390 (ACDK45_09390) corC 1880272..1881171 (+) 900 WP_044364861.1 CNNM family magnesium/cobalt transport protein CorC -

Sequence

Protein


Download         Length: 406 a.a.        Molecular weight: 46259.57 Da        Isoelectric Point: 10.0444

>NTDB_id=1040097 ACDK45_RS09370 WP_011271971.1 1875913..1877133(-) (pilC) [Haemophilus influenzae strain NTHi52]
MTKKLFYYQGSNALNQKQKGSIIADTKQQAHFQLISRGLTHIKLQQNWQFGAKPKNSEISELLNQLATLLQSVIPLKNSL
QILQQNCTQIMLNKWLERLLQSIESGLAFSQAIEQQGKYLTQQEIQLIQVGEMTGKLAVVCKKIATHRSQSLALQRKLQK
IMLYPSMVLGISLLLTLALLLFIAPQFAEMYSGNNAELPTITAILLSISNFLKQNIGILLFFVLSFFLFYYFYLKRQTWF
HQKKNQLISITPIFGTIQKLSRLVNFSQSLQIMLQAGVPLNQALDSFLPRTQTWQTKKTLVNDMVLDKEVRSILQWVSQG
YAFSNSVSSDLFPMEAQQMLQIGEQSGKLALMLEHIADNYQEKLNHQIDLLSQMLEPLMMVIIGSLIGIIMMGMYLPIFN
MGSVIQ

Nucleotide


Download         Length: 1221 bp        

>NTDB_id=1040097 ACDK45_RS09370 WP_011271971.1 1875913..1877133(-) (pilC) [Haemophilus influenzae strain NTHi52]
ATGACTAAAAAACTCTTTTATTATCAAGGTAGTAACGCATTAAATCAGAAACAAAAAGGCTCAATTATTGCGGATACGAA
ACAACAAGCGCACTTTCAGTTAATAAGCCGCGGGCTTACTCACATCAAATTACAACAAAACTGGCAATTTGGGGCAAAAC
CCAAAAATTCAGAAATCAGTGAATTACTCAATCAATTAGCGACATTGCTACAGTCCGTAATTCCGTTAAAAAACAGCCTA
CAAATTTTGCAACAAAATTGTACTCAAATTATGCTCAACAAATGGCTTGAACGACTGCTTCAATCCATTGAATCTGGCTT
AGCATTCTCACAAGCCATTGAACAACAAGGAAAATATCTCACACAACAAGAAATTCAACTGATTCAAGTGGGAGAAATGA
CAGGAAAACTTGCCGTAGTTTGTAAAAAAATAGCCACGCACCGTAGTCAATCTTTGGCTTTACAACGCAAATTACAGAAA
ATTATGTTATATCCCTCAATGGTATTGGGAATTTCTCTATTATTGACACTCGCATTACTGCTTTTTATCGCGCCTCAATT
TGCTGAAATGTACAGTGGCAATAATGCGGAGTTACCAACAATAACCGCAATATTGCTCTCAATATCTAATTTCCTTAAGC
AAAATATTGGCATTTTGCTATTTTTCGTTTTGAGTTTTTTTCTATTTTATTATTTCTATCTAAAACGCCAGACTTGGTTT
CATCAAAAGAAAAATCAACTTATTTCTATCACGCCTATTTTTGGCACAATTCAAAAGCTTTCACGTTTAGTGAACTTTAG
TCAAAGTTTACAAATTATGTTGCAGGCCGGCGTACCGCTTAATCAGGCACTAGACAGTTTTCTTCCTCGCACACAAACTT
GGCAAACCAAGAAAACGCTTGTAAACGATATGGTATTAGATAAAGAAGTGCGGTCAATTTTGCAATGGGTTTCTCAAGGC
TATGCGTTTTCTAATAGCGTAAGTAGCGATCTTTTCCCGATGGAAGCACAACAAATGCTACAAATTGGCGAACAAAGCGG
AAAACTCGCTTTGATGCTAGAGCATATCGCAGATAATTACCAAGAAAAACTTAATCATCAAATTGACTTACTCTCACAAA
TGCTAGAACCATTAATGATGGTAATCATCGGCAGTCTGATTGGGATTATTATGATGGGAATGTATTTACCTATCTTTAAT
ATGGGATCAGTTATTCAATGA

Domains

Predicted by InterproScan.

Type II secretion system (T2SS), protein F (T2SSF)

(63-185)

Type II secretion system (T2SS), protein F (T2SSF)

(266-397)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4QNP6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pilC Haemophilus influenzae 86-028NP

100

100

1
  pilC Haemophilus influenzae Rd KW20

97.783

100

0.978
  pilC Glaesserella parasuis strain SC1401

38.155

98.768

0.377

Multiple sequence alignment