Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   ACB363_RS07535 Genome accession   NZ_CP167021
Coordinates   1471356..1472066 (-) Length   236 a.a.
NCBI ID   WP_002985645.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Isolate 5     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1466356..1477066
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB363_RS07520 (ACB363_07520) rnc 1468063..1468755 (-) 693 WP_002990670.1 ribonuclease III -
  ACB363_RS07525 (ACB363_07525) vicX 1469198..1470007 (-) 810 WP_002985641.1 MBL fold metallo-hydrolase Regulator
  ACB363_RS07530 (ACB363_07530) vicK 1470011..1471363 (-) 1353 WP_002990673.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ACB363_RS07535 (ACB363_07535) vicR 1471356..1472066 (-) 711 WP_002985645.1 response regulator YycF Regulator
  ACB363_RS07540 (ACB363_07540) - 1472228..1473262 (-) 1035 WP_011528375.1 DUF3114 domain-containing protein -
  ACB363_RS07545 (ACB363_07545) - 1473318..1474565 (-) 1248 WP_011528374.1 AMP-binding protein -
  ACB363_RS07550 (ACB363_07550) - 1474522..1475671 (-) 1150 Protein_1445 acetyl-CoA C-acyltransferase -
  ACB363_RS07555 (ACB363_07555) - 1475640..1476209 (-) 570 WP_021299212.1 hypothetical protein -
  ACB363_RS07560 (ACB363_07560) - 1476344..1477057 (-) 714 WP_302479682.1 MIP/aquaporin family protein -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27083.99 Da        Isoelectric Point: 4.9038

>NTDB_id=1037927 ACB363_RS07535 WP_002985645.1 1471356..1472066(-) (vicR) [Streptococcus pyogenes strain Isolate 5]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=1037927 ACB363_RS07535 WP_002985645.1 1471356..1472066(-) (vicR) [Streptococcus pyogenes strain Isolate 5]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACCATTTTTGAAGAAGAAAAGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCCTTTTCTAATCGGGA
ATTGCTGGCGCGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTAACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACTCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGTCAGGTGATGACACGAGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGTCTCCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

90.254

100

0.903
  micA Streptococcus pneumoniae Cp1015

79.06

99.153

0.784
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364

Multiple sequence alignment