Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   ACB344_RS06865 Genome accession   NZ_CP167018
Coordinates   1358222..1360120 (-) Length   632 a.a.
NCBI ID   WP_011018054.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Isolate 8     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1353222..1365120
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB344_RS06840 (ACB344_06840) - 1353958..1354335 (-) 378 WP_002983674.1 S1 RNA-binding domain-containing protein -
  ACB344_RS06845 (ACB344_06845) - 1354335..1355735 (-) 1401 WP_371400030.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  ACB344_RS06850 (ACB344_06850) - 1355772..1356413 (-) 642 WP_002983671.1 response regulator transcription factor -
  ACB344_RS06855 (ACB344_06855) - 1356406..1357410 (-) 1005 WP_011528855.1 sensor histidine kinase -
  ACB344_RS06860 (ACB344_06860) liaF 1357407..1358099 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  ACB344_RS06865 (ACB344_06865) pknB 1358222..1360120 (-) 1899 WP_011018054.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ACB344_RS06870 (ACB344_06870) - 1360117..1360857 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  ACB344_RS06875 (ACB344_06875) rsmB 1360895..1362217 (-) 1323 WP_011528856.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  ACB344_RS06880 (ACB344_06880) fmt 1362207..1363142 (-) 936 WP_011018056.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 632 a.a.        Molecular weight: 68849.09 Da        Isoelectric Point: 7.2899

>NTDB_id=1037766 ACB344_RS06865 WP_011018054.1 1358222..1360120(-) (pknB) [Streptococcus pyogenes strain Isolate 8]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKRYIQNHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKEGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIEENHNVP
QALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYNRSRERKIIFEDVESTKPLPKVASGPTASVKLSPPTPTVLTQESR
LDQTNQTDALQPPTKKKKSGRFLGTLFKILFSFFIVGVALFTYLILTKPTSVKVPNVAGTSLKVAKQELYDVGLKVGKIR
QIESDTVAEGNVVRTDPKAGTAKRQGSSITLYVSIGNKGFDMENYKGLDYQEAMNSLIETYGVPKSKIKIERIVTNEYPE
NTVISQSPSAGDKFNPNGKSKITLSVAVSDTITMPMVTEYSYADAVNTLTALGIDASRIKAYVPSSSSATGFVPIHSPSS
KAIVSGQSPYYGTSLSLSDKGEISLYLYPEETHSSSSSSSSTSSSNSSSTNDSTAPGSNTELSPSETTSQTP

Nucleotide


Download         Length: 1899 bp        

>NTDB_id=1037766 ACB344_RS06865 WP_011018054.1 1358222..1360120(-) (pknB) [Streptococcus pyogenes strain Isolate 8]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGCATTCTGAAATCTATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAATGATTTGATCTTGGATAATGAAGACGTTGCAATCAAGGTCTTGCGTACCAATTATCAAACAGATCAGGTAG
CAGTTGCGCGTTTCCAACGGGAAGCGCGGGCCATGGCTGAATTGAACCATCCCAATATTGTTGCCATCCGGGATATAGGC
GAAGAAGACGGACAGCAATTTTTAGTAATGGAATATGTGGATGGTGCTGACCTAAAGAGATACATTCAAAATCATGCTCC
ATTATCTAATAATGAAGTGGTTAGAATTATGGAAGAAGTCCTTTCTGCTATGACTTTAGCCCACCAAAAAGGAATTGTAC
ACAGAGATTTAAAACCTCAAAATATCCTACTAACTAAGGAGGGGGTTGTCAAAGTAACTGATTTCGGCATCGCAGTAGCC
TTTGCAGAAACAAGCTTGACACAAACTAATTCGATGTTAGGCAGTGTTCATTACTTGTCTCCAGAACAGGCTCGCGGCTC
CAAAGCGACGATTCAAAGTGATATTTATGCGATGGGGATTATGCTCTTTGAGATGTTGACAGGCCATATCCCTTATGATG
GCGATAGTGCTGTTACGATTGCCTTGCAACATTTTCAAAAGCCTCTTCCATCTATTATCGAGGAGAACCACAATGTGCCA
CAAGCTTTGGAGAATGTTGTTATTCGAGCAACAGCCAAGAAATTAAGTGATCGTTACGGGTCAACCTTTGAAATGAGTCG
TGACTTAATGACGGCGCTTAGTTATAATCGTAGTCGGGAGCGTAAGATTATCTTTGAGGATGTTGAAAGTACCAAACCCC
TCCCCAAAGTGGCCTCAGGTCCCACCGCTTCTGTAAAATTGTCTCCCCCTACCCCAACAGTGTTAACACAGGAAAGTCGA
TTAGATCAAACTAATCAAACAGATGCTTTACAGCCCCCCACCAAAAAGAAAAAAAGTGGTCGTTTTTTAGGTACTTTATT
CAAAATTCTTTTTTCTTTCTTTATTGTAGGTGTAGCACTCTTTACTTATCTTATACTAACTAAACCAACTTCTGTGAAAG
TTCCTAATGTAGCAGGCACTAGTCTTAAAGTTGCCAAACAAGAACTGTATGATGTTGGGCTAAAAGTGGGTAAAATCAGG
CAAATTGAGAGTGATACGGTTGCTGAGGGAAATGTAGTTAGAACAGATCCTAAAGCAGGAACAGCTAAGAGGCAAGGCTC
AAGCATTACGCTTTATGTGTCAATTGGAAACAAAGGTTTTGACATGGAAAACTACAAAGGACTAGATTATCAAGAAGCTA
TGAATAGTTTGATAGAAACTTATGGTGTTCCAAAATCAAAAATCAAAATTGAGCGCATTGTAACTAATGAATATCCTGAA
AATACAGTCATCAGTCAATCGCCAAGTGCGGGTGATAAATTTAATCCAAACGGAAAGTCTAAAATTACGCTCAGTGTTGC
TGTTAGTGATACGATCACTATGCCTATGGTAACAGAATATAGTTATGCAGATGCAGTCAATACCTTAACAGCTTTAGGTA
TAGATGCATCTAGAATAAAAGCTTATGTGCCAAGCTCTAGCTCAGCAACGGGCTTTGTGCCAATTCATTCTCCTAGTTCT
AAAGCTATTGTCAGTGGTCAATCCCCTTACTATGGAACGTCTTTGAGTCTGTCTGATAAAGGAGAGATTAGTCTTTACCT
TTATCCAGAAGAAACACACTCTTCTAGTAGCTCATCGAGTTCAACGTCAAGTTCAAACAGTTCTTCAACAAATGATAGTA
CTGCACCAGGTAGCAACACTGAATTAAGCCCATCAGAAACTACTTCTCAAACACCTTAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(372-434)

PASTA domain (PASTA)

(441-506)

PASTA domain (PASTA)

(512-588)

Protein kinase domain (Pkinase)

(12-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.254

93.354

0.609
  stkP/pknB Streptococcus salivarius strain HSISS4

61.345

94.146

0.578
  stkP Streptococcus pneumoniae TIGR4

57.364

81.646

0.468
  stkP Streptococcus pneumoniae D39

57.171

81.646

0.467
  stkP Streptococcus pneumoniae R6

57.171

81.646

0.467
  stkP Streptococcus pneumoniae Rx1

56.977

81.646

0.465

Multiple sequence alignment