Detailed information NTG1037066

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ACB340_RS00330
• Genome accession: NZ_CP167005
• Coordinates: 53223..54125 (+)
• Length: 300 a.a.
• NCBI ID: WP_032460886.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain Isolate 27
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48223..59125

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB340_RS00310 (ACB340_00310)	purE	48507..48998 (+)	492	WP_023079042.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ACB340_RS00315 (ACB340_00315)	purK	48985..50058 (+)	1074	WP_023079033.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ACB340_RS00320 (ACB340_00320)	-	50085..51782 (+)	1698	WP_115224516.1	AIPR family protein	-
ACB340_RS00325 (ACB340_00325)	purB	51800..53092 (+)	1293	WP_023079043.1	adenylosuccinate lyase	-
ACB340_RS00330 (ACB340_00330)	comR	53223..54125 (+)	903	WP_032460886.1	transcriptional regulator Rgg4/ComR	Regulator
ACB340_RS00335 (ACB340_00335)	comS	54209..54304 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
ACB340_RS00340 (ACB340_00340)	ruvB	54351..55349 (+)	999	WP_014407198.1	Holliday junction branch migration DNA helicase RuvB	-
ACB340_RS00345 (ACB340_00345)	-	55487..55924 (+)	438	WP_023079047.1	low molecular weight protein-tyrosine-phosphatase	-
ACB340_RS00350 (ACB340_00350)	-	55947..56348 (+)	402	WP_032465955.1	MORN repeat-containing protein	-
ACB340_RS00355 (ACB340_00355)	-	56345..58120 (+)	1776	WP_023079046.1	acyltransferase family protein	-

Sequence

Protein

• Length: 300 a.a.
• Molecular weight: 35352.85 Da
• Isoelectric Point: 4.5164

>NTDB_id=1037066 ACB340_RS00330 WP_032460886.1 53223..54125(+) (comR) [Streptococcus pyogenes strain Isolate 27]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMAKIQ
DWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 903 bp

>NTDB_id=1037066 ACB340_RS00330 WP_032460886.1 53223..54125(+) (comR) [Streptococcus pyogenes strain Isolate 27]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTGATATTTCAT
CACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCGAAAATTCAA
GATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAATAAAAGCAGA
ACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTCAAGAGTGGG
AAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-293)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	99.01	100	1
comR	Streptococcus pyogenes MGAS315	58.472	100	0.587
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.546	97	0.5
comR	Streptococcus mutans UA159	46.358	100	0.467