Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   ACB350_RS06870 Genome accession   NZ_CP166999
Coordinates   1329999..1331897 (-) Length   632 a.a.
NCBI ID   WP_115346604.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Isolate 34     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1324999..1336897
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB350_RS06845 (ACB350_06845) - 1325735..1326112 (-) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  ACB350_RS06850 (ACB350_06850) - 1326112..1327512 (-) 1401 WP_011054832.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  ACB350_RS06855 (ACB350_06855) - 1327549..1328190 (-) 642 WP_002983671.1 response regulator transcription factor -
  ACB350_RS06860 (ACB350_06860) - 1328183..1329187 (-) 1005 WP_002991890.1 sensor histidine kinase -
  ACB350_RS06865 (ACB350_06865) liaF 1329184..1329876 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  ACB350_RS06870 (ACB350_06870) pknB 1329999..1331897 (-) 1899 WP_115346604.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ACB350_RS06875 (ACB350_06875) - 1331894..1332634 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  ACB350_RS06880 (ACB350_06880) rsmB 1332672..1333994 (-) 1323 WP_030127280.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  ACB350_RS06885 (ACB350_06885) fmt 1333984..1334919 (-) 936 WP_030127281.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 632 a.a.        Molecular weight: 68849.09 Da        Isoelectric Point: 7.2899

>NTDB_id=1036770 ACB350_RS06870 WP_115346604.1 1329999..1331897(-) (pknB) [Streptococcus pyogenes strain Isolate 34]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKRYIQNHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKEGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIEENHNVP
QALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYNRSRERKIIFEDVESTKPLPKVASGPTASVKLSPPTPTVLTQESR
LDQTNQTDTLQPPTKKKKSGRFLGTLFKILFSFFIVGVALFTYLILTKPTSVKVPNVAGSSLKVAKQELYDVGLKVGKIR
QIESDTVAEGNVVRTDPKAGTAKRQGSSITLYVSIGNKGFDMENYKGLDYQEAMNSLIETYGVPKSKIKIERIVTNEYPE
NTVISQSPSAGDKFNPNGKSKITLSVAVSDTITMPMVTEYSYADAVNTLTALGIDASRIKAYVPSSSSATGFVPIHSPSS
KAIVSGQSPYYGTSLSLSDKGEISLYLYPEETHSSSSSSSSTSSSNSSSTNDSTAPGSNTELSPSETTAQTP

Nucleotide


Download         Length: 1899 bp        

>NTDB_id=1036770 ACB350_RS06870 WP_115346604.1 1329999..1331897(-) (pknB) [Streptococcus pyogenes strain Isolate 34]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGCATTCTGAAATCTATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAATGATTTGATCTTGGATAATGAAGACGTTGCAATCAAGGTCTTGCGTACCAATTATCAAACAGATCAGGTAG
CAGTTGCGCGTTTCCAACGAGAAGCGCGGGCCATGGCTGAATTGAACCATCCCAATATTGTTGCCATCCGGGATATAGGT
GAAGAAGACGGACAGCAATTTTTAGTAATGGAATATGTGGATGGTGCTGACCTAAAGAGATACATTCAAAATCATGCTCC
ATTATCTAATAATGAAGTGGTTAGAATTATGGAAGAAGTCCTTTCTGCTATGACTTTAGCCCACCAAAAAGGAATTGTAC
ACAGAGATTTAAAACCTCAAAATATCCTACTAACTAAGGAGGGTGTTGTCAAAGTAACTGATTTCGGCATCGCAGTAGCT
TTTGCAGAAACAAGCTTGACACAAACTAATTCGATGTTAGGCAGTGTTCATTACTTGTCTCCAGAACAGGCTCGCGGCTC
CAAAGCGACGATTCAAAGTGATATTTATGCGATGGGGATTATGCTCTTTGAGATGTTGACAGGCCATATCCCTTATGATG
GCGATAGTGCTGTTACGATTGCCTTGCAACATTTTCAAAAACCTCTTCCATCTATTATTGAGGAGAACCACAATGTGCCA
CAAGCTTTGGAGAATGTTGTTATTCGAGCAACAGCCAAGAAATTAAGTGATCGTTACGGGTCAACCTTTGAAATGAGTCG
TGACTTAATGACGGCGCTTAGTTATAATCGTAGTCGGGAGCGTAAGATTATCTTTGAGGATGTTGAAAGTACCAAACCCC
TCCCCAAAGTGGCCTCAGGTCCCACCGCTTCTGTAAAATTGTCTCCCCCTACCCCAACAGTGTTAACACAGGAAAGTCGA
TTAGATCAAACTAATCAAACAGATACTTTACAGCCCCCCACCAAAAAGAAAAAAAGTGGTCGTTTTTTAGGTACTTTATT
CAAAATTCTTTTTTCTTTCTTTATTGTAGGTGTAGCACTCTTTACTTATCTTATACTAACTAAACCAACTTCTGTGAAAG
TTCCTAATGTAGCAGGCTCTAGTCTTAAAGTTGCCAAACAAGAACTGTATGATGTTGGGCTAAAAGTGGGTAAAATCAGG
CAAATTGAGAGTGATACGGTTGCTGAGGGAAATGTAGTTAGAACAGATCCTAAAGCAGGAACAGCTAAGAGGCAAGGCTC
AAGCATTACGCTTTATGTGTCAATTGGAAACAAAGGTTTTGACATGGAAAACTACAAAGGACTAGATTATCAAGAAGCTA
TGAATAGTTTGATAGAAACTTATGGTGTTCCAAAATCAAAAATCAAAATTGAGCGCATTGTAACTAATGAATATCCTGAA
AATACAGTCATCAGTCAATCACCAAGTGCGGGTGATAAATTTAATCCAAACGGAAAGTCTAAAATTACGCTCAGTGTTGC
TGTTAGTGATACGATCACTATGCCTATGGTAACAGAATATAGTTATGCAGATGCAGTCAATACTTTAACAGCTTTAGGTA
TAGATGCATCTAGAATAAAAGCTTATGTGCCAAGCTCTAGCTCAGCAACGGGCTTTGTGCCAATTCATTCTCCTAGTTCT
AAAGCTATTGTCAGTGGTCAATCTCCTTACTATGGAACGTCTTTGAGTCTGTCTGATAAAGGAGAGATTAGTCTTTACCT
TTATCCAGAAGAAACACACTCTTCTAGTAGCTCATCGAGTTCAACGTCAAGTTCAAACAGTTCTTCAACAAATGATAGTA
CTGCACCAGGTAGCAACACTGAATTAAGCCCATCAGAAACTACTGCTCAAACACCTTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-242)

PASTA domain (PASTA)

(441-506)

PASTA domain (PASTA)

(372-434)

PASTA domain (PASTA)

(512-588)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.424

93.354

0.611
  stkP/pknB Streptococcus salivarius strain HSISS4

61.345

94.146

0.578
  stkP Streptococcus pneumoniae TIGR4

58.008

81.013

0.47
  stkP Streptococcus pneumoniae D39

57.812

81.013

0.468
  stkP Streptococcus pneumoniae R6

57.812

81.013

0.468
  stkP Streptococcus pneumoniae Rx1

57.617

81.013

0.467

Multiple sequence alignment