Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   ACB356_RS01370 Genome accession   NZ_CP166998
Coordinates   253535..254296 (+) Length   253 a.a.
NCBI ID   WP_371395882.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Isolate 35     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 248535..259296
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB356_RS01355 (ACB356_01355) - 248793..250361 (-) 1569 WP_002991130.1 ABC transporter substrate-binding protein/permease -
  ACB356_RS01360 (ACB356_01360) - 250559..252484 (+) 1926 WP_002991128.1 DUF2207 domain-containing protein -
  ACB356_RS01365 (ACB356_01365) - 252550..253389 (+) 840 WP_002991126.1 undecaprenyl-diphosphate phosphatase -
  ACB356_RS01370 (ACB356_01370) mecA 253535..254296 (+) 762 WP_371395882.1 adaptor protein MecA Regulator
  ACB356_RS01375 (ACB356_01375) - 254303..255472 (+) 1170 WP_002991122.1 glycosyltransferase family 4 protein -
  ACB356_RS01380 (ACB356_01380) sufC 255594..256364 (+) 771 WP_002986023.1 Fe-S cluster assembly ATPase SufC -
  ACB356_RS01385 (ACB356_01385) sufD 256459..257721 (+) 1263 WP_002991119.1 Fe-S cluster assembly protein SufD -
  ACB356_RS01390 (ACB356_01390) - 257752..258978 (+) 1227 WP_002991117.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29055.71 Da        Isoelectric Point: 4.1622

>NTDB_id=1036689 ACB356_RS01370 WP_371395882.1 253535..254296(+) (mecA) [Streptococcus pyogenes strain Isolate 35]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADTSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=1036689 ACB356_RS01370 WP_371395882.1 253535..254296(+) (mecA) [Streptococcus pyogenes strain Isolate 35]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCCACTCTAGCTAATCAGTCTGAGGCGGCTGATACATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

64.4

98.814

0.636
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

47.431

100

0.474
  mecA Streptococcus pneumoniae D39

47.431

100

0.474
  mecA Streptococcus pneumoniae R6

47.431

100

0.474
  mecA Streptococcus pneumoniae TIGR4

47.431

100

0.474

Multiple sequence alignment