Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   AB6M99_RS08045 Genome accession   NZ_CP163513
Coordinates   1673688..1675577 (-) Length   629 a.a.
NCBI ID   WP_121835783.1    Uniprot ID   -
Organism   Streptococcus hillyeri strain S23-3001-2     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1668688..1680577
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AB6M99_RS08020 (AB6M99_08020) - 1668904..1669266 (-) 363 WP_121835778.1 S1 RNA-binding domain-containing protein -
  AB6M99_RS08025 (AB6M99_08025) - 1669266..1670666 (-) 1401 WP_121835779.1 Cof-type HAD-IIB family hydrolase -
  AB6M99_RS08030 (AB6M99_08030) - 1670795..1671430 (-) 636 WP_121835780.1 response regulator transcription factor -
  AB6M99_RS08035 (AB6M99_08035) - 1671420..1672427 (-) 1008 WP_121835781.1 sensor histidine kinase -
  AB6M99_RS08040 (AB6M99_08040) liaF 1672424..1673119 (-) 696 WP_121835782.1 cell wall-active antibiotics response protein LiaF -
  AB6M99_RS08045 (AB6M99_08045) pknB 1673688..1675577 (-) 1890 WP_121835783.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  AB6M99_RS08050 (AB6M99_08050) - 1675574..1676314 (-) 741 WP_121835784.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  AB6M99_RS08055 (AB6M99_08055) rsmB 1676357..1677679 (-) 1323 WP_369350518.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  AB6M99_RS08060 (AB6M99_08060) fmt 1677669..1678604 (-) 936 WP_121835786.1 methionyl-tRNA formyltransferase -
  AB6M99_RS08065 (AB6M99_08065) - 1678642..1679313 (-) 672 WP_121835787.1 YdcF family protein -

Sequence

Protein


Download         Length: 629 a.a.        Molecular weight: 69230.40 Da        Isoelectric Point: 5.6826

>NTDB_id=1030305 AB6M99_RS08045 WP_121835783.1 1673688..1675577(-) (pknB) [Streptococcus hillyeri strain S23-3001-2]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEEVAIKVLRTNYQTDQVAVARFQREARAMAELSHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKYIHDHGPLSNEEVIRIMRQVLSAMTLAHQKGIIHRDLKPQNVLLTRDGRAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIAENNTVP
QALENVVLRATAKKLTDRYVSTYQMIRDLSSALDSGRARERRLTFDDGMQSKTSLPKVETNTAKTPRDKLLKPTPEPEIG
QAAPEILENQEQASQKVNKKKRHPIATLFKIFLGVLLLFSILFGYLALSTPPSVTIPDIVGQTQEEATHSLEDAGLKLGK
VYEIDNDSIEAGRVVKTNPTAGSNRKKGSKVDLYVSLGHKSFEMPNYTGQTYEQAKKELIETYHVAEENISYENIEGTEF
EVGTIISQTPEAGTTYTITDSTKIVFKVATKDNIIMPNVTTDESGNALTYNQAVTILTTLGISESRIKFYTQSEAGYVEV
KKPSRGSVIVAQEPYYGEAISVKGKGDIALYIQGDITTTTLTETTASHSESASVSENTTVSEAETSATN

Nucleotide


Download         Length: 1890 bp        

>NTDB_id=1030305 AB6M99_RS08045 WP_121835783.1 1673688..1675577(-) (pknB) [Streptococcus hillyeri strain S23-3001-2]
ATGATTCAGATTGGCAAATTGTTTGCTGGTCGGTATCGTATTCTCAAATCTATTGGTCGTGGTGGCATGGCCGATGTATA
CTTGGCAAATGACCTGATTTTGGACAATGAGGAAGTCGCTATTAAGGTGCTTCGGACTAATTATCAGACGGACCAAGTTG
CTGTCGCTCGTTTCCAACGTGAAGCGCGTGCCATGGCAGAACTTTCTCACCCTAATATTGTTGCGATTCGTGACATTGGT
GAGGAAGATGGTCAACAATTTCTTGTTATGGAATATGTTGACGGTTCAGATTTGAAGAAATATATTCATGACCACGGACC
TTTATCAAATGAAGAAGTCATTCGCATCATGAGACAGGTCTTGTCAGCGATGACGTTAGCTCACCAAAAAGGGATTATTC
ACCGAGACTTGAAACCTCAGAATGTGCTTTTGACTAGAGATGGTAGAGCCAAGGTGACGGATTTTGGGATTGCGGTGGCC
TTTGCTGAAACCAGTTTGACCCAAACCAATTCAATGCTCGGGTCAGTGCATTATTTATCACCTGAACAGGCGCGTGGTTC
TAAAGCAACCATTCAAAGTGATATTTATGCCATGGGGATTATGCTGTTTGAAATGTTGACCGGACATATCCCTTACGATG
GTGATTCAGCCGTAACGATTGCTCTGCAGCATTTTCAAAAACCATTGCCGTCGATTATAGCAGAAAATAACACCGTGCCA
CAGGCTTTGGAAAATGTTGTTTTGCGTGCGACAGCTAAAAAGTTGACAGATCGTTACGTTTCGACTTATCAAATGATTAG
AGACCTTTCTTCAGCACTGGATTCTGGTCGAGCAAGAGAGCGCCGTTTGACATTTGATGACGGTATGCAATCGAAAACTA
GCTTACCTAAAGTTGAAACCAATACAGCTAAAACACCTCGTGATAAGCTATTAAAACCAACCCCAGAACCTGAAATAGGG
CAAGCAGCCCCAGAAATCTTGGAAAATCAAGAGCAAGCCTCACAAAAAGTAAACAAGAAAAAACGTCATCCAATCGCAAC
ACTCTTTAAAATCTTTTTAGGAGTTCTGTTGTTGTTTAGTATCCTCTTTGGTTACTTGGCGCTTTCAACGCCACCTTCAG
TCACTATTCCTGATATTGTTGGTCAAACGCAGGAAGAGGCAACGCATTCTCTTGAAGATGCTGGTCTGAAGCTAGGAAAA
GTTTACGAAATTGATAATGACTCTATTGAGGCTGGAAGAGTGGTCAAAACGAATCCTACAGCAGGGTCAAACCGCAAAAA
AGGCTCTAAAGTTGATTTATACGTTTCCTTAGGTCATAAGAGTTTTGAAATGCCAAACTACACAGGTCAAACTTACGAAC
AGGCTAAAAAAGAATTAATCGAAACTTATCATGTCGCAGAAGAAAATATCAGCTATGAGAATATTGAAGGAACTGAATTT
GAGGTAGGAACAATTATTTCTCAAACGCCAGAAGCTGGGACTACTTATACGATTACAGATTCAACAAAAATTGTTTTTAA
GGTTGCGACTAAAGATAACATTATCATGCCAAATGTGACGACAGATGAGTCTGGTAATGCACTGACTTACAATCAAGCAG
TTACCATATTAACTACTTTGGGAATCTCAGAGTCACGGATTAAATTTTACACTCAGTCTGAAGCCGGTTATGTTGAGGTG
AAAAAACCAAGTCGCGGTAGTGTTATTGTTGCTCAAGAACCTTACTATGGAGAAGCGATTTCAGTCAAAGGCAAAGGAGA
TATAGCTCTGTACATCCAGGGAGATATTACCACAACAACCCTTACTGAAACAACGGCTAGCCACAGTGAATCAGCAAGCG
TATCTGAAAATACAACTGTTAGCGAAGCAGAAACGAGTGCGACCAATTAG

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(374-436)

PASTA domain (PASTA)

(443-508)

Protein kinase domain (Pkinase)

(12-235)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

60.98

94.118

0.574
  stkP/pknB Streptococcus salivarius strain HSISS4

59.699

95.072

0.568
  stkP Streptococcus pneumoniae TIGR4

55.978

87.758

0.491
  stkP Streptococcus pneumoniae D39

57.143

84.579

0.483
  stkP Streptococcus pneumoniae R6

57.143

84.579

0.483
  stkP Streptococcus pneumoniae Rx1

56.955

84.579

0.482

Multiple sequence alignment