Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   DQN40_RS10320 Genome accession   NZ_LS483413
Coordinates   2035426..2036166 (-) Length   246 a.a.
NCBI ID   WP_003061418.1    Uniprot ID   Q8KQN2
Organism   Streptococcus dysgalactiae subsp. equisimilis strain NCTC7136     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 2030426..2041166
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQN40_RS10290 (NCTC7136_02133) - 2031324..2032028 (-) 705 WP_111679434.1 N-acetylmannosamine-6-phosphate 2-epimerase -
  DQN40_RS10300 (NCTC7136_02134) rpmH 2032359..2032493 (-) 135 WP_002885866.1 50S ribosomal protein L34 -
  DQN40_RS10305 (NCTC7136_02135) jag 2032806..2033720 (-) 915 WP_003062632.1 RNA-binding cell elongation regulator Jag/EloR -
  DQN40_RS10310 (NCTC7136_02136) - 2033732..2034559 (-) 828 WP_111679436.1 YidC/Oxa1 family membrane protein insertase -
  DQN40_RS10315 (NCTC7136_02137) rnpA 2034525..2034884 (-) 360 WP_003056083.1 ribonuclease P protein component -
  DQN40_RS10320 (NCTC7136_02138) comE/blpR 2035426..2036166 (-) 741 WP_003061418.1 LytTR family DNA-binding domain-containing protein Regulator
  DQN40_RS10325 (NCTC7136_02139) - 2036170..2037453 (-) 1284 WP_065956858.1 sensor histidine kinase -
  DQN40_RS10330 (NCTC7136_02140) - 2037454..2038797 (-) 1344 WP_048327180.1 GHKL domain-containing protein -
  DQN40_RS10335 (NCTC7136_02141) gltX 2039412..2040860 (-) 1449 WP_003053372.1 glutamate--tRNA ligase -

Sequence

Protein


Download         Length: 246 a.a.        Molecular weight: 28977.28 Da        Isoelectric Point: 4.8645

>NTDB_id=1023657 DQN40_RS10320 WP_003061418.1 2035426..2036166(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC7136]
MMNIFILEDDFIQQTRIESVVADILEEAKIPCNQLEVFANPHKLFESIQERGDHQLYFLDIEIGDEDRRGLELAADIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAVDKQQFRDQIEECIRYTYEMMSSRESEDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFDNGDSCMVSRLKMKCLFE
KWEALH

Nucleotide


Download         Length: 741 bp        

>NTDB_id=1023657 DQN40_RS10320 WP_003061418.1 2035426..2036166(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC7136]
ATGATGAATATTTTTATTCTTGAAGATGATTTTATCCAACAGACACGTATTGAATCTGTAGTGGCAGACATCTTGGAAGA
AGCTAAAATCCCTTGTAATCAGCTAGAAGTGTTTGCCAATCCTCATAAATTATTTGAAAGCATTCAAGAAAGAGGCGATC
ACCAGCTATATTTTTTAGACATTGAGATTGGTGATGAGGATCGCCGAGGGCTTGAATTGGCAGCAGATATTCGACAAAAA
GACCCCAATGCGGTCATTGTGTTTGTTACCACACATTCTGAATTTGCTCCTATTTCTTTTAAATACAAAGTGTCTGCCTT
AGATTTTATTGACAAAGCAGTTGATAAACAACAATTTAGGGATCAGATTGAAGAATGTATCCGCTATACCTATGAGATGA
TGTCTAGCCGAGAATCAGAAGACATGTTTTTATTTGAGACCCCTCAGACAAGGTTAAAATTACCTTACAAAGATATCCTT
TATTTTGCTACTGCTACGACACCCCACAAGGTGTGTTTGTGGACTCAGACGGAGAGACTGGAGTTTTATGGTAATTTATC
TGAGATACAAGCTGTGGCTCCAAAGCTTTTCTTATGCCATAGATCTTACTTGGTTAATCTAGATAAGGTTGTGCGTATTG
ATAAATCCAAACAGCTCCTCTATTTCGATAATGGGGATTCCTGTATGGTCTCACGCTTAAAAATGAAATGCCTTTTTGAA
AAATGGGAAGCCTTACATTAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-123)

LytTr DNA-binding domain (LytTR)

(152-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8KQN2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

47.699

97.154

0.463
  comE/comE1 Streptococcus equinus JB1

42.437

96.748

0.411
  comE/comE2 Streptococcus equinus JB1

40.408

99.593

0.402
  comE/comE2 Streptococcus gordonii strain NCTC7865

39.113

100

0.394
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

39.113

100

0.394