Detailed information NTG1020677

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: AB1F71_RS05270
• Genome accession: NZ_CP160386
• Coordinates: 1069613..1070287 (-)
• Length: 224 a.a.
• NCBI ID: WP_002262214.1
• Uniprot ID: Q8DU28
• Organism: Streptococcus mutans strain UA159 ykuR deletion
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1064613..1075287

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AB1F71_RS05245 (AB1F71_05245)	-	1064920..1066197 (-)	1278	WP_002262219.1	pyrimidine-nucleoside phosphorylase	-
AB1F71_RS05250 (AB1F71_05250)	-	1066306..1066902 (-)	597	WP_002262218.1	class I SAM-dependent methyltransferase	-
AB1F71_RS05255 (AB1F71_05255)	coaA	1066998..1067918 (+)	921	WP_002262217.1	type I pantothenate kinase	-
AB1F71_RS05260 (AB1F71_05260)	rpsT	1067972..1068226 (+)	255	WP_011074586.1	30S ribosomal protein S20	-
AB1F71_RS05265 (AB1F71_05265)	ciaH	1068316..1069623 (-)	1308	WP_002262215.1	three-component system sensor histidine kinase CiaH	Regulator
AB1F71_RS05270 (AB1F71_05270)	ciaR	1069613..1070287 (-)	675	WP_002262214.1	three-component system response regulator CiaR	Regulator
AB1F71_RS05275 (AB1F71_05275)	ciaX	1070338..1070601 (-)	264	WP_002262213.1	three-component system regulator CiaX	-
AB1F71_RS05280 (AB1F71_05280)	-	1071002..1073551 (-)	2550	WP_002262212.1	M1 family metallopeptidase	-
AB1F71_RS05285 (AB1F71_05285)	phoU	1073592..1074245 (-)	654	WP_002262211.1	phosphate signaling complex protein PhoU	-
AB1F71_RS05290 (AB1F71_05290)	pstB	1074277..1075035 (-)	759	WP_002352282.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25475.23 Da
• Isoelectric Point: 4.3425

>NTDB_id=1020677 AB1F71_RS05270 WP_002262214.1 1069613..1070287(-) (ciaR) [Streptococcus mutans strain UA159 ykuR deletion]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLTYGELTVDTATNTTMVNGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFGKNLQTLRSVGYILKDAN

Nucleotide

• Length: 675 bp

>NTDB_id=1020677 AB1F71_RS05270 WP_002262214.1 1069613..1070287(-) (ciaR) [Streptococcus mutans strain UA159 ykuR deletion]
ATGATAAAGTTATTATTAGTAGAAGACGATTTGAGTCTATCTAACTCTATCTTTGACTTTCTGGATGATTTTGCTGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGACTGTATGAAGCAGAGAGTGGCGTTTATGATTTGATTCTATTAGACTTAATGC
TTCCTGAAAAAAATGGCTTCCAAGTTTTAAAAGAACTGCGTGAAAAAGGGATAACGACACCTGTTTTGATTATGACAGCT
AAGGAAGGTTTGGATGACAAAGGACACGGTTTTGAATTAGGAGCTGATGATTATCTGACAAAACCATTTTATCTTGAAGA
ATTAAAAATGCGTATTCAGGCCCTCCTCAAACGTTCAGGCAAATTCAACGAAAATAATCTGACTTACGGTGAGTTAACCG
TTGATACAGCAACTAATACAACAATGGTAAATGGAAAAGAAGTTGAACTGCTTGGCAAAGAGTTTGACTTATTAGTTTAT
TTCTTACAAAATCAAAATGTCATTTTACCTAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGCGATACGACAAT
TTCGGTTGTTGAAGTCTATGTTTCTAAAATAAGAAAGAAATTAAAAGACACCACATTTGGAAAGAATTTACAGACATTAC
GCAGTGTAGGATATATTTTGAAGGATGCTAATTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: Q8DU28

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	100	100	1
ciaR	Streptococcus pneumoniae Rx1	88.393	100	0.884
ciaR	Streptococcus pneumoniae D39	88.393	100	0.884
ciaR	Streptococcus pneumoniae R6	88.393	100	0.884
ciaR	Streptococcus pneumoniae TIGR4	88.393	100	0.884
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.611	100	0.379
vicR	Streptococcus mutans UA159	35.622	100	0.371