Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DQL34_RS04910 Genome accession   NZ_LS483339
Coordinates   915372..916046 (+) Length   224 a.a.
NCBI ID   WP_084828742.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain NCTC12958     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 910372..921046
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL34_RS04890 (NCTC12958_01016) - 911501..912073 (-) 573 WP_002948204.1 ECF transporter S component -
  DQL34_RS04895 (NCTC12958_01017) coaC 912101..912646 (-) 546 WP_100273743.1 phosphopantothenoylcysteine decarboxylase -
  DQL34_RS04900 (NCTC12958_01018) - 912639..913322 (-) 684 WP_084828741.1 phosphopantothenate--cysteine ligase -
  DQL34_RS04905 (NCTC12958_01019) - 913516..915186 (+) 1671 WP_024704082.1 formate--tetrahydrofolate ligase -
  DQL34_RS04910 (NCTC12958_01020) ciaR 915372..916046 (+) 675 WP_084828742.1 response regulator transcription factor Regulator
  DQL34_RS12595 (NCTC12958_01021) ciaH 916036..916275 (+) 240 WP_409350141.1 histidine kinase Regulator
  DQL34_RS11910 (NCTC12958_01023) - 916420..917456 (+) 1037 Protein_919 sensor histidine kinase -
  DQL34_RS04930 - 917557..919127 (+) 1571 WP_106693466.1 IS3-like element ISSth1b family transposase -
  DQL34_RS04935 (NCTC12958_01026) rpsT 919492..919728 (-) 237 WP_084825632.1 30S ribosomal protein S20 -
  DQL34_RS04940 (NCTC12958_01027) coaA 919797..920717 (-) 921 WP_023909573.1 type I pantothenate kinase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25404.92 Da        Isoelectric Point: 4.1229

>NTDB_id=1018562 DQL34_RS04910 WP_084828742.1 915372..916046(+) (ciaR) [Streptococcus thermophilus strain NCTC12958]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLKELREQGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTFSFGDVCVNLSTNSTYVGDEEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTNVSVVEVYVSKIRKKLKGTDFATNLQTLRSVGYILKNAD

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1018562 DQL34_RS04910 WP_084828742.1 915372..916046(+) (ciaR) [Streptococcus thermophilus strain NCTC12958]
ATGATTAAAATTTTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCGGATGT
GATGCAAGTATTTGATGGAGATGAAGGTCTTTACGAAGCTGAAAGTGGTGTTTATGATTTGATTCTTTTGGACTTAATGT
TACCTGAAAAAGATGGTTTTACAGTTCTTAAAGAATTGCGTGAACAAGGAATAACGACTCCTGTTCTTATCATGACTGCT
AAGGAAAGTCTAGACGATAAGGGGCATGGCTTCGAACTCGGAGCTGATGATTATCTAACCAAGCCTTTCTATTTAGAAGA
ATTGAAGATGCGTATTCAGGCACTTTTGAAACGTTCTGGTAAATTTGATCAAAATACTTTTTCTTTTGGAGATGTTTGTG
TCAACCTTTCTACAAATTCAACTTATGTGGGTGATGAAGAAGTAGAACTTCTTGGTAAAGAATTTGATTTATTAGTCTAC
TTCCTACAAAATCAAAACGTTATTTTGCCCAAGTCGCAAATCTTTGATCGTCTTTGGGGATTTGATAGTGATACCAATGT
CTCTGTTGTTGAAGTTTATGTTTCGAAAATTCGTAAGAAACTTAAGGGGACTGATTTTGCTACCAACCTACAAACCTTAA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae D39

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae R6

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae TIGR4

87.444

99.554

0.871
  ciaR Streptococcus mutans UA159

85.268

100

0.853
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.889

100

0.371
  vicR Streptococcus mutans UA159

34.746

100

0.366