Detailed information NTG1018353

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: DQL03_RS02345
• Genome accession: NZ_LS483337
• Coordinates: 424095..426248 (-)
• Length: 717 a.a.
• NCBI ID: WP_111674850.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC12047
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 419095..431248

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL03_RS02325 (NCTC12047_00462)	comE/blpR	420286..421035 (+)	750	WP_030126108.1	response regulator transcription factor	Regulator
DQL03_RS02330 (NCTC12047_00463)	-	421036..422370 (+)	1335	WP_063631787.1	sensor histidine kinase	-
DQL03_RS02335 (NCTC12047_00464)	-	422518..422643 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
DQL03_RS02340 (NCTC12047_00465)	-	422720..424084 (-)	1365	WP_111674849.1	bacteriocin secretion accessory protein	-
DQL03_RS02345 (NCTC12047_00466)	comA/nlmT	424095..426248 (-)	2154	WP_111674850.1	peptide cleavage/export ABC transporter	Regulator
DQL03_RS02350 (NCTC12047_00467)	-	426531..426758 (+)	228	WP_002992018.1	Blp family class II bacteriocin	-
DQL03_RS02355 (NCTC12047_00468)	-	426771..426971 (+)	201	WP_002990771.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
DQL03_RS02375 (NCTC12047_00471)	-	427985..428386 (+)	402	WP_023605036.1	hypothetical protein	-
DQL03_RS02380 (NCTC12047_00472)	-	428637..429707 (+)	1071	WP_063628997.1	hypothetical protein	-
DQL03_RS02385 (NCTC12047_00473)	-	429800..430198 (+)	399	WP_032464238.1	hypothetical protein	-
DQL03_RS02390 (NCTC12047_00474)	stcA	430546..430815 (-)	270	WP_023605037.1	quorum-sensing system protein StcA	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80546.50 Da
• Isoelectric Point: 7.1729

>NTDB_id=1018353 DQL03_RS02345 WP_111674850.1 424095..426248(-) (comA/nlmT) [Streptococcus pyogenes strain NCTC12047]
MISYRKTFVAQTDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLISFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILKQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIEIGSHQELMTKQGFYHHLFSS

Nucleotide

• Length: 2154 bp

>NTDB_id=1018353 DQL03_RS02345 WP_111674850.1 424095..426248(-) (comA/nlmT) [Streptococcus pyogenes strain NCTC12047]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGACTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGATTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAGCTTTTTACCTCTC
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCAAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAC
GTCATTTTATCTTACATTCGCCATATTTTTGAGCTTCCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATCTC
ACGTTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTTCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGCTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCCTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACTAAACTGCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAGTTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCACTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAATAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTAGTTAA

Domains

Predicted by InterProScan.

• ABC transporter (ABC_tran) (500-649)

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter transmembrane region (ABC_membrane) (168-438)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.587	99.721	0.724
comA	Streptococcus mitis NCTC 12261	67.507	99.582	0.672
comA	Streptococcus mitis SK321	67.087	99.582	0.668
comA	Streptococcus pneumoniae Rx1	67.087	99.582	0.668
comA	Streptococcus pneumoniae D39	67.087	99.582	0.668
comA	Streptococcus pneumoniae R6	67.087	99.582	0.668
comA	Streptococcus pneumoniae TIGR4	66.807	99.582	0.665
comA	Streptococcus gordonii str. Challis substr. CH1	65.877	100	0.66