Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP/pknB   Type   Regulator
Locus tag   H1W81_RS04125 Genome accession   NZ_LR824002
Coordinates   778784..780655 (+) Length   623 a.a.
NCBI ID   WP_011226292.1    Uniprot ID   Q5M3J0
Organism   Streptococcus thermophilus isolate STH_CIRM_67     
Function   activate comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 773784..785655
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W81_RS04110 (STHERMO_0892) fmt 775756..776691 (+) 936 WP_002951411.1 methionyl-tRNA formyltransferase -
  H1W81_RS04115 (STHERMO_0893) rsmB 776681..778003 (+) 1323 WP_014608533.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  H1W81_RS04120 (STHERMO_0894) - 778047..778784 (+) 738 WP_002946881.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  H1W81_RS04125 (STHERMO_0895) stkP/pknB 778784..780655 (+) 1872 WP_011226292.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  H1W81_RS09475 (STHERMO_0898) - 781292..781447 (+) 156 WP_011226290.1 ion channel -
  H1W81_RS04135 (STHERMO_0899) liaF 781713..782411 (+) 699 WP_011226289.1 cell wall-active antibiotics response protein LiaF -
  H1W81_RS04140 (STHERMO_0900) - 782408..783418 (+) 1011 WP_011227402.1 sensor histidine kinase -
  H1W81_RS04145 (STHERMO_0901) vraR 783408..784052 (+) 645 WP_002951384.1 response regulator transcription factor Regulator
  H1W81_RS04160 (STHERMO_0902) rimM 784724..785242 (+) 519 WP_011226286.1 ribosome maturation factor RimM -

Sequence

Protein


Download         Length: 623 a.a.        Molecular weight: 67919.80 Da        Isoelectric Point: 7.1310

>NTDB_id=1012157 H1W81_RS04125 WP_011226292.1 778784..780655(+) (stkP/pknB) [Streptococcus thermophilus isolate STH_CIRM_67]
MIQVGKLFAGRYRILKSIGRGGMADVYLANDLILDNESVAIKVLRTNYQTDQVAVARFQREARAMTELSHPNIVAIRDIG
EEDGQQFLVMEYVDGSDLKKFIQDHAPLSNQDVVRIMGEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGRAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPFDGDSAVTIALQHFQKPLPSILAENRNVP
QALENVVIRATAKKLENRYNSTLEMSRDLVTSLHPSHSRDSKVVFDDMTDAKTLPKVDSVSSVGPEKKISPKPSEPTPAP
SKQPREKASLSKKKKNLFSTLLKVLLGFVFIGIIIFAYLVFTNPDNVQVPNVVGQELSTAQTKLESAGFKVGDVKEVEND
SVNKGKVIKTDPTAGTMRKEGASIDVYVSSGSKGFTLKNYKGKNYKDAIEDLTSNYGVSEDQIDIQHVEDDNAKEGEILS
QSSEKNKSFNPKDSKAKIKFRVATPKTITMPDVTGLTVSTAVQTLNSKDISSSSIEYHDYNTGVKLDKSKVPSNTEVLYQ
YPQVGTAVDGTVILYVSVVTKSSSIQQSSTASTTQSPSSTSSSSESSTASSTETATEATHTEQ

Nucleotide


Download         Length: 1872 bp        

>NTDB_id=1012157 H1W81_RS04125 WP_011226292.1 778784..780655(+) (stkP/pknB) [Streptococcus thermophilus isolate STH_CIRM_67]
ATGATCCAAGTTGGCAAATTGTTTGCTGGACGTTATCGAATCCTTAAATCTATCGGACGTGGTGGTATGGCGGATGTTTA
TCTGGCTAACGACCTGATTCTGGATAATGAAAGTGTAGCTATTAAGGTGCTACGTACCAATTATCAAACTGATCAGGTTG
CTGTGGCGCGTTTCCAGCGTGAAGCACGTGCCATGACTGAGCTTAGCCATCCGAATATCGTTGCGATTAGAGATATTGGT
GAAGAAGACGGTCAGCAGTTCTTGGTGATGGAGTATGTGGATGGTTCGGACTTGAAGAAATTCATTCAAGACCATGCACC
ATTGTCTAACCAAGATGTTGTGCGTATTATGGGGGAAGTCCTTTCCGCCATGACTCTTGCCCACCAAAAGGGTATTATTC
ACCGTGACCTTAAGCCACAGAACGTTCTATTAACTAAGGATGGTAGAGCTAAGGTTACAGACTTTGGTATCGCAGTAGCA
TTTGCTGAAACCAGCCTGACACAAACTAACTCAATGTTGGGGTCAGTCCATTATTTGTCACCAGAACAGGCACGTGGTTC
TAAAGCCACTATCCAAAGTGATATCTATGCTATGGGGATTATGCTCTTTGAAATGTTGACAGGGCATATCCCTTTTGATG
GCGATAGTGCAGTAACCATTGCACTTCAACATTTCCAAAAGCCCCTGCCATCGATTTTGGCTGAGAACCGTAACGTTCCT
CAAGCTTTAGAAAATGTTGTTATTAGAGCAACTGCTAAAAAGCTTGAAAATCGTTACAACAGCACTTTGGAAATGAGTCG
CGACCTAGTAACTAGTTTGCATCCTAGTCATAGTCGTGATTCTAAGGTAGTTTTTGATGACATGACGGATGCTAAGACCC
TGCCAAAGGTTGATTCAGTTTCATCAGTAGGTCCTGAGAAAAAGATTTCTCCTAAACCATCAGAGCCTACACCGGCTCCA
AGCAAACAACCGAGGGAAAAAGCTTCTCTATCTAAAAAAAAGAAAAATCTCTTTTCAACTCTACTCAAGGTTTTACTAGG
CTTCGTCTTTATAGGAATTATCATTTTTGCCTATCTTGTTTTTACCAATCCTGACAATGTCCAAGTACCAAATGTTGTAG
GTCAAGAGTTGTCAACAGCTCAGACGAAACTTGAAAGTGCAGGCTTTAAGGTTGGCGATGTTAAAGAAGTCGAAAATGAT
TCAGTCAATAAGGGCAAAGTTATCAAGACCGACCCTACAGCTGGGACAATGCGTAAAGAGGGAGCAAGCATTGATGTCTA
TGTTTCTTCTGGTAGCAAAGGTTTCACTCTGAAAAATTACAAGGGGAAAAATTATAAGGATGCCATTGAGGATTTAACCT
CGAATTATGGGGTTTCCGAGGATCAGATCGATATTCAACATGTCGAAGACGATAATGCTAAAGAAGGCGAAATTCTATCT
CAAAGTTCGGAGAAAAACAAGTCCTTCAATCCTAAAGATAGTAAGGCAAAAATCAAGTTTCGTGTGGCAACTCCTAAGAC
TATAACTATGCCTGATGTGACTGGTTTAACTGTCTCGACAGCAGTCCAAACCTTGAATAGTAAAGACATTTCAAGTAGCA
GTATTGAGTATCATGACTATAATACTGGTGTTAAGTTGGATAAGAGTAAGGTACCTAGTAATACCGAGGTCCTTTATCAA
TATCCTCAAGTTGGTACTGCTGTTGATGGCACAGTGATTCTCTATGTTTCAGTCGTAACTAAGAGTTCAAGTATTCAACA
GTCAAGCACAGCAAGTACGACACAATCGCCGTCATCTACAAGTTCTAGTTCTGAAAGTAGTACAGCTTCTAGTACCGAAA
CAGCTACAGAAGCTACTCACACAGAGCAATAA

Domains

Predicted by InterProScan.

Protein kinase domain (Pkinase)

(12-235)

PASTA domain (PASTA)

(508-577)

PASTA domain (PASTA)

(367-429)

PASTA domain (PASTA)

(436-502)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q5M3J0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP/pknB Streptococcus salivarius strain HSISS4

90.361

93.258

0.843
  pknB Streptococcus mutans UA159

64.522

87.319

0.563
  stkP Streptococcus pneumoniae TIGR4

56.713

80.096

0.454
  stkP Streptococcus pneumoniae D39

56.513

80.096

0.453
  stkP Streptococcus pneumoniae R6

56.513

80.096

0.453
  stkP Streptococcus pneumoniae Rx1

56.313

80.096

0.451

Multiple sequence alignment