Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   FGL00_RS02645 Genome accession   NZ_LR594034
Coordinates   498829..500982 (-) Length   717 a.a.
NCBI ID   WP_138098286.1    Uniprot ID   -
Organism   Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 493829..505982
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL00_RS02615 (NCTC8546_00539) comE/blpR 493843..494592 (+) 750 WP_065358564.1 response regulator transcription factor Regulator
  FGL00_RS02620 (NCTC8546_00540) - 494593..495927 (+) 1335 WP_065358565.1 GHKL domain-containing protein -
  FGL00_RS02625 (NCTC8546_00541) - 496075..496200 (-) 126 WP_011017462.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  FGL00_RS02630 (NCTC8546_00542) - 496277..497383 (-) 1107 WP_343233178.1 bacteriocin secretion accessory protein -
  FGL00_RS02635 (NCTC8546_00543) - 497441..498463 (-) 1023 WP_172600594.1 IS30 family transposase -
  FGL00_RS02640 (NCTC8546_00544) - 498552..498818 (-) 267 Protein_459 bacteriocin ABC transporter ATP-binding protein -
  FGL00_RS02645 (NCTC8546_00545) comA/nlmT 498829..500982 (-) 2154 WP_138098286.1 peptide cleavage/export ABC transporter Regulator
  FGL00_RS02650 (NCTC8546_00546) - 501269..501496 (+) 228 WP_042361549.1 Blp family class II bacteriocin -
  FGL00_RS02655 (NCTC8546_00547) - 501509..501709 (+) 201 WP_003060803.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  FGL00_RS02665 (NCTC8546_00548) - 502003..502197 (+) 195 WP_002990768.1 hypothetical protein -
  FGL00_RS02670 (NCTC8546_00549) - 502247..502528 (+) 282 WP_111676660.1 hypothetical protein -
  FGL00_RS02675 (NCTC8546_00550) - 502722..503132 (+) 411 WP_138098288.1 hypothetical protein -
  FGL00_RS02680 - 503375..503626 (+) 252 WP_000973012.1 hypothetical protein -
  FGL00_RS02685 - 503654..503899 (+) 246 WP_232043401.1 CPBP family intramembrane glutamic endopeptidase -
  FGL00_RS11120 (NCTC8546_00551) - 504204..504620 (+) 417 WP_232043429.1 hypothetical protein -
  FGL00_RS11125 (NCTC8546_00552) - 504642..505049 (+) 408 WP_232043402.1 hypothetical protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80570.61 Da        Isoelectric Point: 7.6085

>NTDB_id=1004919 FGL00_RS02645 WP_138098286.1 498829..500982(-) (comA/nlmT) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLISFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEKNRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HADIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMINKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIEIGSHQELMTKQGFYHHLFSS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=1004919 FGL00_RS02645 WP_138098286.1 498829..500982(-) (comA/nlmT) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGATTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAGCTTTTTACCTCTC
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAC
GTCATTTTATCTTACATTCGCCATATTTTTGAGCTTCCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATCTC
ACGTTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTTCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAAAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCCTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACTAAACTGCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAGTTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGCAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTAATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCACTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAATAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTAGTTAA

Domains

Predicted by InterProScan.

ABC transporter transmembrane region (ABC_membrane)

(168-438)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-649)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

72.587

99.721

0.724
  comA Streptococcus mitis NCTC 12261

67.367

99.582

0.671
  comA Streptococcus mitis SK321

66.947

99.582

0.667
  comA Streptococcus pneumoniae Rx1

66.947

99.582

0.667
  comA Streptococcus pneumoniae D39

66.947

99.582

0.667
  comA Streptococcus pneumoniae R6

66.947

99.582

0.667
  comA Streptococcus pneumoniae TIGR4

66.667

99.582

0.664
  comA Streptococcus gordonii str. Challis substr. CH1

66.156

100

0.662