Detailed information NTG1001860

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ABC807_RS08495
• Genome accession: NZ_CP156625
• Coordinates: 1628481..1629218 (-)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain TL7/1993
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1623481..1634218

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC807_RS08475 (ABC807_08475)	comA/nlmT	1623858..1625501 (+)	1644	WP_078133841.1	peptide cleavage/export ABC transporter	Regulator
ABC807_RS08480 (ABC807_08480)	-	1625512..1626873 (+)	1362	WP_001069091.1	bacteriocin secretion accessory protein	-
ABC807_RS08485 (ABC807_08485)	blpC	1626930..1627085 (+)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
ABC807_RS08490 (ABC807_08490)	-	1627127..1628467 (-)	1341	WP_001017638.1	sensor histidine kinase	-
ABC807_RS08495 (ABC807_08495)	comE/blpR	1628481..1629218 (-)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
ABC807_RS08500 (ABC807_08500)	-	1629223..1629561 (-)	339	WP_000682135.1	LytTR family DNA-binding domain-containing protein	-
ABC807_RS08505 (ABC807_08505)	-	1629838..1630167 (+)	330	WP_000132572.1	hypothetical protein	-
ABC807_RS08510 (ABC807_08510)	-	1630335..1631384 (-)	1050	WP_000653767.1	ABC transporter permease	-
ABC807_RS08515 (ABC807_08515)	pptA	1631381..1632112 (-)	732	WP_000889925.1	ABC transporter ATP-binding protein	Regulator
ABC807_RS08520 (ABC807_08520)	-	1632180..1632590 (+)	411	WP_001278299.1	HIT family protein	-
ABC807_RS08525 (ABC807_08525)	-	1632600..1632887 (+)	288	WP_000777760.1	hypothetical protein	-
ABC807_RS08530 (ABC807_08530)	-	1633049..1633288 (+)	240	WP_001810235.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=1001860 ABC807_RS08495 WP_001219120.1 1628481..1629218(-) (comE/blpR) [Streptococcus pneumoniae strain TL7/1993]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=1001860 ABC807_RS08495 WP_001219120.1 1628481..1629218(-) (comE/blpR) [Streptococcus pneumoniae strain TL7/1993]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363