Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Xre-RelE
Location 1756100..1756739 Replicon chromosome
Accession NC_007146
Organism Haemophilus influenzae 86-028NP

Toxin (Protein)


Gene name higB Uniprot ID Q4QJX7
Locus tag NTHI_RS08835 Protein ID WP_005650215.1
Coordinates 1756434..1756739 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NTHI_RS08830 Protein ID WP_005650217.1
Coordinates 1756100..1756423 (-) Length 108 a.a.

Genomic Context

NTHI_RS08840NTHI_RS08845NTHI_RS08855NTHI_RS09945NTHI_RS08815NTHI_RS08820NTHI_RS08825NTHI_RS08830NTHI_RS08835
Location: 1757064..1757684 (621 bp)
Type: Others
Protein ID: WP_005694310.1
Location: 1757687..1758655 (969 bp)
Type: Others
Protein ID: WP_011272702.1
Location: 1759269..1761308 (2040 bp)
Type: Others
Protein ID: WP_011272703.1
Location: 1751719..1751892 (174 bp)
Type: Others
Protein ID: WP_011272700.1
Location: 1751889..1753859 (1971 bp)
Type: Others
Protein ID: WP_011272701.1
Location: 1753864..1754205 (342 bp)
Type: Others
Protein ID: WP_005652996.1
Location: 1754267..1755937 (1671 bp)
Type: Others
Protein ID: WP_005650218.1
Location: 1756100..1756423 (324 bp)
Type: Antitoxin
Protein ID: WP_005650217.1
Location: 1756434..1756739 (306 bp)
Type: Toxin
Protein ID: WP_005650215.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NTHI_RS09945 (NTHI1907)1751719..1751892-174WP_011272700.1DUF5363 domain-containing protein-
NTHI_RS08815 (NTHI1908)1751889..1753859-1971WP_011272701.1tRNA(Met) cytidine acetyltransferase TmcA-
NTHI_RS08820 (NTHI1910)1753864..1754205-342WP_005652996.1SirB2 family protein-
NTHI_RS08825 (NTHI1911)1754267..1755937-1671WP_005650218.1energy-dependent translational throttle protein EttA-
NTHI_RS08830 (NTHI1912)1756100..1756423-324WP_005650217.1HigA family addiction module antidote proteinAntitoxin
NTHI_RS08835 (NTHI1913)1756434..1756739-306WP_005650215.1type II toxin-antitoxin system RelE/ParE family toxinToxin
NTHI_RS08840 (NTHI1914)1757064..1757684+621WP_005694310.1zinc transporter binding subunit ZevA-
NTHI_RS08845 (NTHI1915)1757687..1758655+969WP_011272702.1zinc transporter permease subunit ZevB-
NTHI_RS08855 (NTHI1917)1759269..1761308+2040WP_011272703.1excinuclease ABC subunit B-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-99)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12301.93 Da        Isoelectric Point: 9.0853

>T6124 WP_005650215.1 NC_007146:c1756739-1756434 [Haemophilus influenzae 86-028NP]
MFNLKREHFRDDYLYRFYQYGDTHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

>T6124 NC_007146:c1756739-1756434 [Haemophilus influenzae 86-028NP]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATACTCATAGTAAGAT
TCCTTCTAATTTGTATAAAGTATTGGCAAGAAAATTAGATATGATAAGTGCCTCAGAAAATATCAACGATTTACGTTCTC
CACCAGCTAACCATTTGGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCTATTCGAGTGAATAAACAATATCGTTTA
ATTTTTAAATATGAAAATAACGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12347.17 Da        Isoelectric Point: 6.8804

>AT6124 WP_005650217.1 NC_007146:c1756423-1756100 [Haemophilus influenzae 86-028NP]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Download         Length: 324 bp

>AT6124 NC_007146:c1756423-1756100 [Haemophilus influenzae 86-028NP]
ATGATGACGAGAAAACCCACCTCTGTTGGTGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAGTGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGCAAGCAATATTGTTAATAATAGTTCACGAATTACGCTAGAAATGG
CAGTTAAACTTGCTAAAGTATTTGATACTACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGGACCTT
GAACACAATAAACGTTTTCAACAAAGTCTTGCAAATGTTAAGCCCGCTCTACATCGGCATGATACTTCTACATTTGCAAT
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T171Vibrio cholerae O1 biovar El Tor str. N16961

46.154

95.789

0.442

T6083Pseudomonas putida KT2440

36.957

100

0.37

T10032Pseudomonas aeruginosa PAO1

37.179

84.783

0.315

T10161Pseudomonas aeruginosa PA14 strain MA3 isolate DTU_MIE

37.179

84.783

0.315
Showing 1 to 4 of 4 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT171Vibrio cholerae O1 biovar El Tor str. N16961

47.826

87.619

0.419

AT6083Pseudomonas putida KT2440

42.308

78.788

0.333
Showing 1 to 2 of 2 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A806EC70

Antitoxin

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Source
ID
Structure
No matching records found

References

(1) Dabin Ren et al. (2014) The ToxAvapA toxin-antitoxin locus contributes to the survival of nontypeable Haemophilus influenzae during infection. PloS One 9(3):e91523. [PubMed:24621787] experimental


experimental experimental literature