Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 415424..416057 Replicon chromosome
Accession NZ_CP013320
Organism Vibrio cholerae strain NCTC9420

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag ASZ86_RS16635 Protein ID WP_000843587.1
Coordinates 415424..415756 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ASZ86_RS16640 Protein ID WP_000071008.1
Coordinates 415743..416057 (+) Length 105 a.a.

Genomic Context

ASZ86_RS20720ASZ86_RS20530ASZ86_RS16575ASZ86_RS20835ASZ86_RS16590ASZ86_RS16595ASZ86_RS16600ASZ86_RS20810ASZ86_RS16605ASZ86_RS16620ASZ86_RS16625ASZ86_RS16635ASZ86_RS16640ASZ86_RS16645ASZ86_RS20650ASZ86_RS16665ASZ86_RS16670ASZ86_RS16675ASZ86_RS20545ASZ86_RS16685ASZ86_RS16690ASZ86_RS16695ASZ86_RS16660
Location: 410865..411068 (204 bp)
Type: Others
Protein ID: WP_001911745.1
Location: 411349..411522 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 411882..412151 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 412469..412640 (172 bp)
Type: Others
Protein ID: Protein_434
Location: 412849..413235 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 413437..413679 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 413850..414227 (378 bp)
Type: Others
Protein ID: WP_071919850.1
Location: 414284..414398 (115 bp)
Type: Others
Protein ID: Protein_438
Location: 414347..414628 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 414794..414907 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 414856..415083 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 415424..415756 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 415743..416057 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 416194..416628 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 416796..416951 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 418124..418430 (307 bp)
Type: Others
Protein ID: Protein_447
Location: 418567..419259 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 419259..419660 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 419630..419773 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 419848..420261 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 420475..420726 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 420716..421003 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 417076..418056 (981 bp)
Type: Others
Protein ID: WP_000019370.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ86_RS20720410865..411068+204WP_001911745.1hypothetical protein-
ASZ86_RS20530411349..411522+174WP_001882305.1DUF3709 domain-containing protein-
ASZ86_RS16575411882..412151+270WP_001198131.1hypothetical protein-
ASZ86_RS20835412469..412640+172Protein_434DUF645 family protein-
ASZ86_RS16590412849..413235+387WP_000703163.1VOC family protein-
ASZ86_RS16595413437..413679+243WP_000107461.1hypothetical protein-
ASZ86_RS16600413850..414227+378WP_071919850.1hypothetical protein-
ASZ86_RS20810414284..414398+115Protein_438acetyltransferase-
ASZ86_RS16605414347..414628+282WP_001894453.1DUF1289 domain-containing protein-
ASZ86_RS16620414794..414907+114WP_001889158.1hypothetical protein-
ASZ86_RS16625414856..415083+228WP_001894457.1DUF1289 domain-containing protein-
ASZ86_RS16635415424..415756+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ86_RS16640415743..416057+315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
ASZ86_RS16645416194..416628+435WP_000256036.1GNAT family N-acetyltransferase-
ASZ86_RS20650416796..416951+156WP_000751734.1hypothetical protein-
ASZ86_RS16660417076..418056-981WP_000019370.1IS5-like element ISVch5 family transposase-
ASZ86_RS16665418124..418430+307Protein_447CatB-related O-acetyltransferase-
ASZ86_RS16670418567..419259+693WP_001047169.1GNAT family N-acetyltransferase-
ASZ86_RS16675419259..419660+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
ASZ86_RS20545419630..419773+144WP_071908341.1DUF3265 domain-containing protein-
ASZ86_RS16685419848..420261+414WP_000049417.1VOC family protein-
ASZ86_RS16690420475..420726+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ86_RS16695420716..421003+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--304702..436238131536
-insideIntegron--309782..435862126080
flankIS/Tn--417076..418056980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T58424 WP_000843587.1 NZ_CP013320:415424-415756 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T58424 NZ_CP013320:415424-415756 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT58424 WP_000071008.1 NZ_CP013320:415743-416057 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT58424 NZ_CP013320:415743-416057 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References