Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
Location | 822720..823353 | Replicon | chromosome |
Accession | NZ_CP013312 | ||
Organism | Vibrio cholerae strain E1320 |
Toxin (Protein)
Gene name | higB | Uniprot ID | Q9KMA6 |
Locus tag | ASZ88_RS18400 | Protein ID | WP_000843587.1 |
Coordinates | 822720..823052 (+) | Length | 111 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | ASZ88_RS18405 | Protein ID | WP_000071008.1 |
Coordinates | 823039..823353 (+) | Length | 105 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ASZ88_RS21080 | 818161..818364 | + | 204 | WP_001911745.1 | hypothetical protein | - |
ASZ88_RS20870 | 818645..818818 | + | 174 | WP_001882305.1 | DUF3709 domain-containing protein | - |
ASZ88_RS18340 | 819178..819447 | + | 270 | WP_001198131.1 | hypothetical protein | - |
ASZ88_RS21230 | 819765..819936 | + | 172 | Protein_822 | DUF645 family protein | - |
ASZ88_RS18355 | 820145..820531 | + | 387 | WP_000703163.1 | VOC family protein | - |
ASZ88_RS18360 | 820733..820975 | + | 243 | WP_000107461.1 | hypothetical protein | - |
ASZ88_RS18365 | 821146..821523 | + | 378 | WP_000411109.1 | hypothetical protein | - |
ASZ88_RS21210 | 821580..821694 | + | 115 | Protein_826 | acetyltransferase | - |
ASZ88_RS18370 | 821643..821924 | + | 282 | WP_001894453.1 | DUF1289 domain-containing protein | - |
ASZ88_RS18385 | 822090..822203 | + | 114 | WP_001889158.1 | hypothetical protein | - |
ASZ88_RS18390 | 822152..822379 | + | 228 | WP_001894457.1 | DUF1289 domain-containing protein | - |
ASZ88_RS18400 | 822720..823052 | + | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
ASZ88_RS18405 | 823039..823353 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
ASZ88_RS18410 | 823490..823924 | + | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
ASZ88_RS20985 | 824092..824247 | + | 156 | WP_000751734.1 | hypothetical protein | - |
ASZ88_RS18425 | 824372..825352 | - | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
ASZ88_RS18430 | 825420..825726 | + | 307 | Protein_835 | CatB-related O-acetyltransferase | - |
ASZ88_RS18435 | 825863..826555 | + | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
ASZ88_RS18440 | 826555..826956 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
ASZ88_RS20885 | 826926..827069 | + | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
ASZ88_RS18450 | 827144..827557 | + | 414 | WP_000049417.1 | VOC family protein | - |
ASZ88_RS18455 | 827771..828022 | + | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
ASZ88_RS18460 | 828012..828299 | + | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 688711..843534 | 154823 | |
- | inside | Integron | catB9 | - | 693791..843158 | 149367 | |
flank | IS/Tn | - | - | 824372..825352 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T58338 WP_000843587.1 NZ_CP013312:822720-823052 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T58338 NZ_CP013312:822720-823052 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT58338 WP_000071008.1 NZ_CP013312:823039-823353 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT58338 NZ_CP013312:823039-823353 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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