58338

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 822720..823353 Replicon chromosome
Accession NZ_CP013312
Organism Vibrio cholerae strain E1320

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag ASZ88_RS18400 Protein ID WP_000843587.1
Coordinates 822720..823052 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ASZ88_RS18405 Protein ID WP_000071008.1
Coordinates 823039..823353 (+) Length 105 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ88_RS21080 818161..818364 + 204 WP_001911745.1 hypothetical protein -
ASZ88_RS20870 818645..818818 + 174 WP_001882305.1 DUF3709 domain-containing protein -
ASZ88_RS18340 819178..819447 + 270 WP_001198131.1 hypothetical protein -
ASZ88_RS21230 819765..819936 + 172 Protein_822 DUF645 family protein -
ASZ88_RS18355 820145..820531 + 387 WP_000703163.1 VOC family protein -
ASZ88_RS18360 820733..820975 + 243 WP_000107461.1 hypothetical protein -
ASZ88_RS18365 821146..821523 + 378 WP_000411109.1 hypothetical protein -
ASZ88_RS21210 821580..821694 + 115 Protein_826 acetyltransferase -
ASZ88_RS18370 821643..821924 + 282 WP_001894453.1 DUF1289 domain-containing protein -
ASZ88_RS18385 822090..822203 + 114 WP_001889158.1 hypothetical protein -
ASZ88_RS18390 822152..822379 + 228 WP_001894457.1 DUF1289 domain-containing protein -
ASZ88_RS18400 822720..823052 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ88_RS18405 823039..823353 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
ASZ88_RS18410 823490..823924 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
ASZ88_RS20985 824092..824247 + 156 WP_000751734.1 hypothetical protein -
ASZ88_RS18425 824372..825352 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
ASZ88_RS18430 825420..825726 + 307 Protein_835 CatB-related O-acetyltransferase -
ASZ88_RS18435 825863..826555 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
ASZ88_RS18440 826555..826956 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
ASZ88_RS20885 826926..827069 + 144 WP_071908341.1 DUF3265 domain-containing protein -
ASZ88_RS18450 827144..827557 + 414 WP_000049417.1 VOC family protein -
ASZ88_RS18455 827771..828022 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ88_RS18460 828012..828299 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 688711..843534 154823
- inside Integron catB9 - 693791..843158 149367
flank IS/Tn - - 824372..825352 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-100)

Antitoxin

(43-92)


Sequences


Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T58338 WP_000843587.1 NZ_CP013312:822720-823052 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T58338 NZ_CP013312:822720-823052 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT58338 WP_000071008.1 NZ_CP013312:823039-823353 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT58338 NZ_CP013312:823039-823353 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA


Antitoxin

Source ID Structure

References