Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 67299..67932 | Replicon | chromosome |
| Accession | NZ_AP024556 | ||
| Organism | Vibrio cholerae strain IDH-03506 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | K6J79_RS14375 | Protein ID | WP_000843587.1 |
| Coordinates | 67299..67631 (+) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | K6J79_RS14380 | Protein ID | WP_000071008.1 |
| Coordinates | 67618..67932 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6J79_RS14320 | 62740..62943 | + | 204 | WP_001911745.1 | hypothetical protein | - |
| K6J79_RS14325 | 63200..63397 | + | 198 | WP_001894451.1 | DUF3709 domain-containing protein | - |
| K6J79_RS14330 | 63757..64026 | + | 270 | WP_001198131.1 | hypothetical protein | - |
| K6J79_RS14335 | 64362..64515 | + | 154 | Protein_130 | DUF645 family protein | - |
| K6J79_RS14340 | 64724..65110 | + | 387 | WP_000703163.1 | VOC family protein | - |
| K6J79_RS14345 | 65195..65554 | + | 360 | WP_226979446.1 | pullulanase | - |
| K6J79_RS14350 | 65725..66102 | + | 378 | WP_000411109.1 | hypothetical protein | - |
| K6J79_RS14355 | 66159..66273 | + | 115 | Protein_134 | acetyltransferase | - |
| K6J79_RS14360 | 66282..66503 | + | 222 | WP_032468461.1 | DUF1289 domain-containing protein | - |
| K6J79_RS14365 | 66669..66782 | + | 114 | WP_001889158.1 | hypothetical protein | - |
| K6J79_RS14370 | 66731..66958 | + | 228 | WP_073426587.1 | DUF1289 domain-containing protein | - |
| K6J79_RS14375 | 67299..67631 | + | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K6J79_RS14380 | 67618..67932 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
| K6J79_RS14385 | 68069..68503 | + | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
| K6J79_RS14390 | 68671..68826 | + | 156 | WP_000751734.1 | hypothetical protein | - |
| K6J79_RS14395 | 68951..69931 | - | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
| K6J79_RS14400 | 69999..70305 | + | 307 | Protein_143 | CatB-related O-acetyltransferase | - |
| K6J79_RS19000 | 70442..70840 | + | 399 | Protein_144 | GNAT family N-acetyltransferase | - |
| K6J79_RS19005 | 70964..71134 | + | 171 | WP_001080654.1 | hypothetical protein | - |
| K6J79_RS14410 | 71134..71535 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| K6J79_RS19010 | 71538..71648 | + | 111 | WP_082798255.1 | DUF3265 domain-containing protein | - |
| K6J79_RS14415 | 71723..72136 | + | 414 | WP_000049417.1 | VOC family protein | - |
| K6J79_RS14420 | 72350..72601 | + | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| K6J79_RS14425 | 72591..72878 | + | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | cqsA / ugd / htpB / hlyA / hcp-2 / vgrG-2 / vipA/mglA / vipB/mglB / VCA0109 / vasA / vasB / vasC / vasD / vasE / vasF / clpB/vasG / vasH / vasI / vasJ / icmF/vasK / vasL / vgrG-3 / hlyA | 3..1061958 | 1061955 | |
| flank | IS/Tn | - | - | 68951..69931 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T38695 WP_000843587.1 NZ_AP024556:67299-67631 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T38695 NZ_AP024556:67299-67631 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT38695 WP_000071008.1 NZ_AP024556:67618-67932 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT38695 NZ_AP024556:67618-67932 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|