Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 1531543..1532176 | Replicon | chromosome |
| Accession | NZ_AP018677 | ||
| Organism | Vibrio cholerae strain V060002 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | V060002_RS07460 | Protein ID | WP_000843587.1 |
| Coordinates | 1531844..1532176 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | V060002_RS07455 | Protein ID | WP_000071008.1 |
| Coordinates | 1531543..1531857 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| V060002_RS07410 | 1526597..1526884 | - | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| V060002_RS07415 | 1526874..1527125 | - | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| V060002_RS07420 | 1527339..1527752 | - | 414 | WP_000049417.1 | VOC family protein | - |
| V060002_RS07425 | 1527827..1527970 | - | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
| V060002_RS07430 | 1527940..1528341 | - | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| V060002_RS07435 | 1528341..1529033 | - | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
| V060002_RS07440 | 1529170..1529476 | - | 307 | Protein_1375 | CatB-related O-acetyltransferase | - |
| V060002_RS07445 | 1529544..1530524 | + | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
| V060002_RS19485 | 1530649..1530804 | - | 156 | WP_000751734.1 | hypothetical protein | - |
| V060002_RS07450 | 1530972..1531406 | - | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
| V060002_RS07455 | 1531543..1531857 | - | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
| V060002_RS07460 | 1531844..1532176 | - | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| V060002_RS07470 | 1532517..1532744 | - | 228 | WP_001894457.1 | DUF1289 domain-containing protein | - |
| V060002_RS07475 | 1532693..1532806 | - | 114 | WP_001889158.1 | hypothetical protein | - |
| V060002_RS07490 | 1532972..1533253 | - | 282 | WP_001894453.1 | DUF1289 domain-containing protein | - |
| V060002_RS19490 | 1533202..1533316 | - | 115 | Protein_1384 | acetyltransferase | - |
| V060002_RS07495 | 1533373..1533750 | - | 378 | WP_000411109.1 | hypothetical protein | - |
| V060002_RS07500 | 1533921..1534163 | - | 243 | WP_000107461.1 | hypothetical protein | - |
| V060002_RS07505 | 1534365..1534751 | - | 387 | WP_000703163.1 | VOC family protein | - |
| V060002_RS19565 | 1534960..1535131 | - | 172 | Protein_1388 | DUF645 family protein | - |
| V060002_RS07515 | 1535449..1535718 | - | 270 | WP_001198131.1 | hypothetical protein | - |
| V060002_RS07520 | 1536078..1536251 | - | 174 | WP_001882305.1 | DUF3709 domain-containing protein | - |
| V060002_RS19505 | 1536532..1536735 | - | 204 | WP_001911745.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 1516275..1622843 | 106568 | |
| flank | IS/Tn | - | - | 1529544..1530524 | 980 | ||
| - | inside | Integron | - | - | 1511738..1563819 | 52081 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T31957 WP_000843587.1 NZ_AP018677:c1532176-1531844 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T31957 NZ_AP018677:c1532176-1531844 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT31957 WP_000071008.1 NZ_AP018677:c1531857-1531543 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT31957 NZ_AP018677:c1531857-1531543 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|