Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 599679..600478 Replicon chromosome
Accession NZ_LR134227
Organism Escherichia coli strain NCTC9102

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag EL093_RS02900 Protein ID WP_000347273.1
Coordinates 599679..600143 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag EL093_RS02905 Protein ID WP_001307405.1
Coordinates 600143..600478 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL093_RS02870 594680..595114 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
EL093_RS02875 595132..596010 - 879 WP_126322955.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
EL093_RS02880 596000..596779 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
EL093_RS02885 596790..597263 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
EL093_RS02890 597286..598566 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
EL093_RS02895 598815..599624 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
EL093_RS02900 599679..600143 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
EL093_RS02905 600143..600478 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
EL093_RS02910 600627..602198 - 1572 WP_001723936.1 galactarate dehydratase -
EL093_RS02915 602573..603907 + 1335 WP_001723935.1 galactarate/glucarate/glycerate transporter GarP -
EL093_RS02920 603923..604693 + 771 WP_001723934.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 599679..611127 11448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T287163 WP_000347273.1 NZ_LR134227:c600143-599679 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT287163 WP_001307405.1 NZ_LR134227:c600478-600143 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References