278701

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 605704..606503 Replicon chromosome
Accession NZ_CP123237
Organism Escherichia coli strain 4588

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QET42_RS02960 Protein ID WP_000347273.1
Coordinates 605704..606168 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QET42_RS02965 Protein ID WP_001307405.1
Coordinates 606168..606503 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET42_RS02930 (600705) 600705..601139 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QET42_RS02935 (601157) 601157..602035 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
QET42_RS02940 (602025) 602025..602804 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QET42_RS02945 (602815) 602815..603288 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QET42_RS02950 (603311) 603311..604591 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
QET42_RS02955 (604840) 604840..605649 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QET42_RS02960 (605704) 605704..606168 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QET42_RS02965 (606168) 606168..606503 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QET42_RS02970 (606652) 606652..608223 - 1572 WP_001723936.1 galactarate dehydratase -
QET42_RS02975 (608598) 608598..609932 + 1335 WP_001723935.1 galactarate/glucarate/glycerate transporter GarP -
QET42_RS02980 (609948) 609948..610718 + 771 WP_001723934.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 605704..617377 11673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T278701 WP_000347273.1 NZ_CP123237:c606168-605704 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278701 WP_001307405.1 NZ_CP123237:c606503-606168 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References