278233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 605689..606488 Replicon chromosome
Accession NZ_CP122929
Organism Escherichia coli strain ETEC1702

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QDX05_RS02960 Protein ID WP_000347273.1
Coordinates 605689..606153 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDX05_RS02965 Protein ID WP_001307405.1
Coordinates 606153..606488 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX05_RS02930 (600690) 600690..601124 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDX05_RS02935 (601142) 601142..602020 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
QDX05_RS02940 (602010) 602010..602789 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDX05_RS02945 (602800) 602800..603273 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDX05_RS02950 (603296) 603296..604576 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDX05_RS02955 (604825) 604825..605634 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDX05_RS02960 (605689) 605689..606153 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDX05_RS02965 (606153) 606153..606488 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDX05_RS02970 (606637) 606637..608208 - 1572 WP_001723936.1 galactarate dehydratase -
QDX05_RS02975 (608583) 608583..609917 + 1335 WP_001723935.1 galactarate/glucarate/glycerate transporter GarP -
QDX05_RS02980 (609933) 609933..610703 + 771 WP_001723934.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 605689..617360 11671


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T278233 WP_000347273.1 NZ_CP122929:c606153-605689 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278233 WP_001307405.1 NZ_CP122929:c606488-606153 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References