277385

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 605705..606504 Replicon chromosome
Accession NZ_CP122625
Organism Escherichia coli strain ETEC4089

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QDW64_RS02955 Protein ID WP_000347273.1
Coordinates 605705..606169 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDW64_RS02960 Protein ID WP_001307405.1
Coordinates 606169..606504 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW64_RS02925 (600706) 600706..601140 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDW64_RS02930 (601158) 601158..602036 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
QDW64_RS02935 (602026) 602026..602805 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDW64_RS02940 (602816) 602816..603289 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDW64_RS02945 (603312) 603312..604592 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDW64_RS02950 (604841) 604841..605650 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDW64_RS02955 (605705) 605705..606169 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDW64_RS02960 (606169) 606169..606504 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDW64_RS02965 (606653) 606653..608224 - 1572 WP_001723936.1 galactarate dehydratase -
QDW64_RS02970 (608599) 608599..609933 + 1335 WP_001723935.1 galactarate/glucarate/glycerate transporter GarP -
QDW64_RS02975 (609949) 609949..610719 + 771 WP_001723934.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 605705..617376 11671


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T277385 WP_000347273.1 NZ_CP122625:c606169-605705 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277385 WP_001307405.1 NZ_CP122625:c606504-606169 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References