277096

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 604474..605273 Replicon chromosome
Accession NZ_CP122507
Organism Escherichia coli strain W444

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QC806_RS02960 Protein ID WP_000347273.1
Coordinates 604474..604938 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QC806_RS02965 Protein ID WP_001307405.1
Coordinates 604938..605273 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC806_RS02930 (599475) 599475..599909 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QC806_RS02935 (599927) 599927..600805 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
QC806_RS02940 (600795) 600795..601574 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QC806_RS02945 (601585) 601585..602058 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QC806_RS02950 (602081) 602081..603361 - 1281 WP_096178318.1 tagatose-bisphosphate aldolase subunit KbaZ -
QC806_RS02955 (603610) 603610..604419 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QC806_RS02960 (604474) 604474..604938 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QC806_RS02965 (604938) 604938..605273 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QC806_RS02970 (605422) 605422..606993 - 1572 WP_001723936.1 galactarate dehydratase -
QC806_RS02975 (607368) 607368..608702 + 1335 WP_001723935.1 galactarate/glucarate/glycerate transporter GarP -
QC806_RS02980 (608718) 608718..609488 + 771 WP_001723934.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 604474..616148 11674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T277096 WP_000347273.1 NZ_CP122507:c604938-604474 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT277096 WP_001307405.1 NZ_CP122507:c605273-604938 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References