261847

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 671829..672628 Replicon chromosome
Accession NZ_CP109601
Organism Escherichia coli strain TL-14

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag OGV15_RS03270 Protein ID WP_000347273.1
Coordinates 671829..672293 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag OGV15_RS03275 Protein ID WP_001307405.1
Coordinates 672293..672628 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGV15_RS03240 (666830) 666830..667264 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
OGV15_RS03245 (667282) 667282..668160 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
OGV15_RS03250 (668150) 668150..668929 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
OGV15_RS03255 (668940) 668940..669413 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
OGV15_RS03260 (669436) 669436..670716 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
OGV15_RS03265 (670965) 670965..671774 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
OGV15_RS03270 (671829) 671829..672293 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
OGV15_RS03275 (672293) 672293..672628 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
OGV15_RS03280 (672777) 672777..674348 - 1572 WP_001723936.1 galactarate dehydratase -
OGV15_RS03285 (674723) 674723..676057 + 1335 WP_001723935.1 galactarate/glucarate/glycerate transporter GarP -
OGV15_RS03290 (676073) 676073..676843 + 771 WP_001723934.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 671829..683501 11672


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T261847 WP_000347273.1 NZ_CP109601:c672293-671829 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT261847 WP_001307405.1 NZ_CP109601:c672628-672293 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References