Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 606083..606882 Replicon chromosome
Accession NZ_CP104618
Organism Escherichia coli strain AHM9C68I

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag N5859_RS02940 Protein ID WP_000347273.1
Coordinates 606083..606547 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag N5859_RS02945 Protein ID WP_001307405.1
Coordinates 606547..606882 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5859_RS02910 (601084) 601084..601518 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
N5859_RS02915 (601536) 601536..602414 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
N5859_RS02920 (602404) 602404..603183 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N5859_RS02925 (603194) 603194..603667 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
N5859_RS02930 (603690) 603690..604970 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
N5859_RS02935 (605219) 605219..606028 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
N5859_RS02940 (606083) 606083..606547 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N5859_RS02945 (606547) 606547..606882 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N5859_RS02950 (607031) 607031..608602 - 1572 WP_001723936.1 galactarate dehydratase -
N5859_RS02955 (608977) 608977..610311 + 1335 WP_001723935.1 galactarate/glucarate/glycerate transporter GarP -
N5859_RS02960 (610327) 610327..611097 + 771 WP_001723934.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 606083..617755 11672


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T258625 WP_000347273.1 NZ_CP104618:c606547-606083 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT258625 WP_001307405.1 NZ_CP104618:c606882-606547 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References