245466

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 604926..605725 Replicon chromosome
Accession NZ_CP097430
Organism Escherichia coli strain C288

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag M8Y68_RS02950 Protein ID WP_000347273.1
Coordinates 604926..605390 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag M8Y68_RS02955 Protein ID WP_001307405.1
Coordinates 605390..605725 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y68_RS02920 (599927) 599927..600361 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
M8Y68_RS02925 (600379) 600379..601257 - 879 WP_001300474.1 PTS N-acetylgalactosamine transporter subunit IID -
M8Y68_RS02930 (601247) 601247..602026 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
M8Y68_RS02935 (602037) 602037..602510 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
M8Y68_RS02940 (602533) 602533..603813 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
M8Y68_RS02945 (604062) 604062..604871 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
M8Y68_RS02950 (604926) 604926..605390 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
M8Y68_RS02955 (605390) 605390..605725 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
M8Y68_RS02960 (605874) 605874..607445 - 1572 WP_001723936.1 galactarate dehydratase -
M8Y68_RS02965 (607820) 607820..609154 + 1335 WP_001723935.1 galactarate/glucarate/glycerate transporter GarP -
M8Y68_RS02970 (609170) 609170..609940 + 771 WP_001723934.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 604926..616598 11672


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T245466 WP_000347273.1 NZ_CP097430:c605390-604926 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT245466 WP_001307405.1 NZ_CP097430:c605725-605390 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References