Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 839109..839742 | Replicon | chromosome |
| Accession | NC_009456 | ||
| Organism | Vibrio cholerae O395 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | VC0395_RS03860 | Protein ID | WP_000843587.1 |
| Coordinates | 839410..839742 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | VC0395_RS03855 | Protein ID | WP_000071008.1 |
| Coordinates | 839109..839423 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VC0395_RS03810 | 834163..834450 | - | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| VC0395_RS03815 | 834440..834691 | - | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| VC0395_RS03820 | 834905..835318 | - | 414 | WP_000049417.1 | VOC family protein | - |
| VC0395_RS20535 | 835393..835536 | - | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
| VC0395_RS03825 | 835506..835907 | - | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| VC0395_RS03830 | 835907..836599 | - | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
| VC0395_RS03835 | 836736..837042 | - | 307 | Protein_739 | CatB-related O-acetyltransferase | - |
| VC0395_RS03840 | 837110..838090 | + | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
| VC0395_RS20945 | 838215..838370 | - | 156 | WP_000751734.1 | hypothetical protein | - |
| VC0395_RS03850 | 838538..838972 | - | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
| VC0395_RS03855 | 839109..839423 | - | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
| VC0395_RS03860 | 839410..839742 | - | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VC0395_RS03870 | 840083..840310 | - | 228 | WP_001894457.1 | DUF1289 domain-containing protein | - |
| VC0395_RS21050 | 840259..840373 | - | 115 | Protein_746 | acetyltransferase | - |
| VC0395_RS21055 | 840490..840661 | - | 172 | Protein_747 | DUF645 family protein | - |
| VC0395_RS03875 | 840979..841248 | - | 270 | WP_001198131.1 | hypothetical protein | - |
| VC0395_RS20700 | 841608..841781 | - | 174 | WP_001882305.1 | DUF3709 domain-containing protein | - |
| VC0395_RS20960 | 842062..842265 | - | 204 | WP_001911745.1 | hypothetical protein | - |
| VC0395_RS03885 | 842552..843103 | - | 552 | WP_000821930.1 | hypothetical protein | - |
| VC0395_RS03890 | 843259..844116 | - | 858 | WP_001279526.1 | DUF2806 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 833458..916350 | 82892 | |
| flank | IS/Tn | - | - | 837110..838090 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T22077 WP_000843587.1 NC_009456:c839742-839410 [Vibrio cholerae O395]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T22077 NC_009456:c839742-839410 [Vibrio cholerae O395]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT22077 WP_000071008.1 NC_009456:c839423-839109 [Vibrio cholerae O395]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT22077 NC_009456:c839423-839109 [Vibrio cholerae O395]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|