206604

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 12050..12683 Replicon chromosome
Accession NZ_CP077061
Organism Vibrio cholerae strain MS84A

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag J3992_RS13645 Protein ID WP_000843587.1
Coordinates 12351..12683 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J3992_RS13640 Protein ID WP_000071008.1
Coordinates 12050..12364 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3992_RS13585 (J3992_13580) 7104..7391 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
J3992_RS13590 (J3992_13585) 7381..7632 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
J3992_RS13595 (J3992_13590) 7846..8259 - 414 WP_000049417.1 VOC family protein -
J3992_RS13600 (J3992_13595) 8334..8444 - 111 WP_082798255.1 DUF3265 domain-containing protein -
J3992_RS13605 (J3992_13600) 8447..8848 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
J3992_RS13610 (J3992_13605) 8848..9018 - 171 WP_001080654.1 hypothetical protein -
J3992_RS13615 (J3992_13610) 9142..9540 - 399 Protein_23 GNAT family N-acetyltransferase -
J3992_RS13620 (J3992_13615) 9677..9983 - 307 Protein_24 CatB-related O-acetyltransferase -
J3992_RS13625 (J3992_13620) 10051..11031 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
J3992_RS13630 (J3992_13625) 11156..11311 - 156 WP_000751734.1 hypothetical protein -
J3992_RS13635 (J3992_13630) 11479..11913 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
J3992_RS13640 (J3992_13635) 12050..12364 - 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
J3992_RS13645 (J3992_13640) 12351..12683 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J3992_RS13650 (J3992_13645) 13024..13251 - 228 WP_001894457.1 DUF1289 domain-containing protein -
J3992_RS13655 (J3992_13650) 13200..13313 - 114 WP_001889158.1 hypothetical protein -
J3992_RS13660 (J3992_13655) 13479..13700 - 222 WP_032468461.1 DUF1289 domain-containing protein -
J3992_RS13665 (J3992_13660) 13709..13823 - 115 Protein_33 acetyltransferase -
J3992_RS13670 (J3992_13665) 13880..14257 - 378 WP_000411109.1 hypothetical protein -
J3992_RS13675 (J3992_13670) 14428..14781 - 354 WP_080032710.1 pullulanase -
J3992_RS13680 (J3992_13675) 14872..15258 - 387 WP_000703163.1 VOC family protein -
J3992_RS13685 (J3992_13680) 15467..15599 - 133 Protein_37 DUF645 family protein -
J3992_RS13690 15590..15715 - 126 WP_080360924.1 general secretion pathway protein GspH -
J3992_RS13695 (J3992_13685) 15956..16225 - 270 WP_001198131.1 hypothetical protein -
J3992_RS13700 (J3992_13690) 16585..16782 - 198 WP_001894451.1 DUF3709 domain-containing protein -
J3992_RS13705 (J3992_13695) 17039..17242 - 204 WP_001911745.1 hypothetical protein -
J3992_RS13710 17383..17448 - 66 Protein_42 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 1..1044173 1044172
flank IS/Tn - - 10051..11031 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T206604 WP_000843587.1 NZ_CP077061:c12683-12351 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T206604 NZ_CP102500:4686776-4687093 [Citrobacter youngae]
ATCATGGAAATTCTTCAGACCACGGTTTTCCAACGCTGGGAACAGAATCTACGGGATCGCAGGGCCAAAACGCTCATTGC
CGCACGACTTTTTCGACTGGCGAATGGTTTAGCTGGCGATGTTAAACCTGTAGGGGAAGGCGTCAGCGAAATGCGCATTT
CTTACGGTCCTGGTTACAGGATTTACTTTAAACAGCATGGCTGCCGCATCATCATTTTGCTATGTGGTGGCGATAAAAGC
TCACAAGCTAACGATATCACCCTTGCAAAAGTGCTCGCCCGTTCACTGGATTATCAGGAGACCTTCCGCCATGAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT206604 WP_000071008.1 NZ_CP077061:c12364-12050 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT206604 NZ_CP102500:4687086-4687364 [Citrobacter youngae]
ATGAATAAGCTTACTCAGTACGATCCCGCAGCTGCGCTGGTTGATGATGAAGAAATTGCTGTATTTATGGCGGATGCCCT
CGAAACAGGCGATGCAACGTACATTGCAAAAGCATTGGGCGTGGTGGCACGCGCTAAGGGAATGGCGAGCATCGCGGCAG
AAACGGGGTTATCCCGCGAACAACTCTATCGCTCGTTTAGTGAGAAAGGAAACCCGACGCTGAAAACCACGCTGGCGGTG
ATGAAGGCGCTCGGTATTGGATTGACACTTAGAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References