Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 988052..989289 Replicon chromosome
Accession NC_003028
Organism Streptococcus pneumoniae TIGR4

Toxin (Protein)


Gene name pezT Uniprot ID Q97QZ1
Locus tag SP_RS05200 Protein ID WP_000405360.1
Coordinates 988528..989289 (+) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag SP_RS05195 Protein ID WP_000579608.1
Coordinates 988052..988528 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SP_RS05170 (SP_1044) 983124..983978 + 855 WP_000900015.1 ADP-ribosylglycohydrolase family protein -
SP_RS05175 (SP_1045) 984090..984974 + 885 WP_000710115.1 diacylglycerol kinase family lipid kinase -
SP_RS12090 985138..985500 + 363 WP_000423476.1 alpha amylase N-terminal ig-like domain-containing protein -
SP_RS05180 (SP_1046) 985481..986877 + 1397 Protein_973 glycoside hydrolase family 13 protein -
SP_RS05185 (SP_1047) 986963..987280 + 318 WP_000995815.1 hypothetical protein -
SP_RS05190 (SP_1048) 987326..987607 + 282 WP_000266234.1 hypothetical protein -
SP_RS05195 (SP_1050) 988052..988528 + 477 WP_000579608.1 helix-turn-helix domain-containing protein Antitoxin
SP_RS05200 (SP_1051) 988528..989289 + 762 WP_000405360.1 toxin PezT Toxin
SP_RS05205 (SP_1052) 989317..990473 + 1157 Protein_978 hypothetical protein -
SP_RS05215 (SP_1054) 991304..991660 + 357 WP_000817623.1 hypothetical protein -
SP_RS05220 (SP_1055) 991665..992030 + 366 WP_000401239.1 MobC family plasmid mobilization relaxosome protein -
SP_RS05225 (SP_1056) 992017..993840 + 1824 WP_000237143.1 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 968351..1022298 53947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29129.20 Da        Isoelectric Point: 7.5087

>T20634 WP_000405360.1 NC_003028:988528-989289 [Streptococcus pneumoniae TIGR4]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Download         Length: 762 bp

>T20634 NC_003028:988528-989289 [Streptococcus pneumoniae TIGR4]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
CACACGAAAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTCTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
CAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18247.70 Da        Isoelectric Point: 4.4188

>AT20634 WP_000579608.1 NC_003028:988052-988528 [Streptococcus pneumoniae TIGR4]
MIGKNIKSLRKTHDLTQLEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT20634 NC_003028:988052-988528 [Streptococcus pneumoniae TIGR4]
ATGATTGGAAAGAACATAAAATCCTTGCGTAAAACACATGACTTAACACAACTCGAATTTGCACGGATTGTAGGTATTTC
ACGAAATAGTCTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
GTCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGATTTGATTCATACGAATATCTATCTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGTGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTGGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2P5T

Antitoxin

Source ID Structure

References