Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-couple_hipB |
| Location | 988311..989548 | Replicon | chromosome |
| Accession | NZ_CP089948 | ||
| Organism | Streptococcus pneumoniae TIGR4 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | Q97QZ1 |
| Locus tag | LXA46_RS04925 | Protein ID | WP_000405360.1 |
| Coordinates | 988787..989548 (+) | Length | 254 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | - |
| Locus tag | LXA46_RS04920 | Protein ID | WP_000579608.1 |
| Coordinates | 988311..988787 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LXA46_RS04900 (LXA46_04890) | 983384..984238 | + | 855 | WP_000900015.1 | ADP-ribosylglycohydrolase family protein | - |
| LXA46_RS04905 (LXA46_04895) | 984350..985234 | + | 885 | WP_000710115.1 | diacylglycerol kinase family lipid kinase | - |
| LXA46_RS04910 (LXA46_04900) | 985397..987136 | + | 1740 | Protein_977 | glycoside hydrolase family 13 protein | - |
| LXA46_RS04915 (LXA46_04905) | 987411..987866 | + | 456 | Protein_978 | hypothetical protein | - |
| LXA46_RS04920 (LXA46_04910) | 988311..988787 | + | 477 | WP_000579608.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| LXA46_RS04925 (LXA46_04915) | 988787..989548 | + | 762 | WP_000405360.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| LXA46_RS04930 (LXA46_04920) | 989576..990352 | + | 777 | WP_001821017.1 | hypothetical protein | - |
| LXA46_RS04935 (LXA46_04925) | 990355..990732 | + | 378 | WP_000530001.1 | hypothetical protein | - |
| LXA46_RS04940 (LXA46_04930) | 991564..991920 | + | 357 | WP_000817623.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| LXA46_RS04945 (LXA46_04935) | 991925..992290 | + | 366 | WP_000401239.1 | MobC family plasmid mobilization relaxosome protein | - |
| LXA46_RS04950 (LXA46_04940) | 992277..994100 | + | 1824 | WP_000237143.1 | SAG1250 family conjugative relaxase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Integrative and Conjugative Element | - | - | 968612..1022558 | 53946 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 254 a.a. Molecular weight: 29129.20 Da Isoelectric Point: 7.5087
>T229786 WP_000405360.1 NZ_CP089948:988787-989548 [Streptococcus pneumoniae TIGR4]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK
Download Length: 762 bp
>T229786 NZ_CP124517:c2554424-2554110 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 159 a.a. Molecular weight: 18247.70 Da Isoelectric Point: 4.4188
>AT229786 WP_000579608.1 NZ_CP089948:988311-988787 [Streptococcus pneumoniae TIGR4]
MIGKNIKSLRKTHDLTQLEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
MIGKNIKSLRKTHDLTQLEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
Download Length: 477 bp
>AT229786 NZ_CP124517:c2554113-2553697 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|