117441

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 988311..989548 Replicon chromosome
Accession NZ_CP035239
Organism Streptococcus pneumoniae strain TVO_TIGR4

Toxin (Protein)


Gene name pezT Uniprot ID Q97QZ1
Locus tag EQH41_RS04915 Protein ID WP_000405360.1
Coordinates 988787..989548 (+) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag EQH41_RS04910 Protein ID WP_000579608.1
Coordinates 988311..988787 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH41_RS04890 (EQH41_05210) 983384..984238 + 855 WP_000900015.1 ADP-ribosylglycohydrolase family protein -
EQH41_RS04895 (EQH41_05215) 984350..985234 + 885 WP_000710115.1 diacylglycerol kinase family lipid kinase -
EQH41_RS04900 (EQH41_05225) 985397..987136 + 1740 Protein_976 glycoside hydrolase family 13 protein -
EQH41_RS04905 987411..987866 + 456 Protein_977 hypothetical protein -
EQH41_RS04910 (EQH41_05240) 988311..988787 + 477 WP_000579608.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
EQH41_RS04915 (EQH41_05245) 988787..989548 + 762 WP_000405360.1 type II toxin-antitoxin system toxin PezT Toxin
EQH41_RS04920 (EQH41_05250) 989576..990352 + 777 WP_001821017.1 hypothetical protein -
EQH41_RS04925 990355..990732 + 378 WP_000530001.1 hypothetical protein -
EQH41_RS04930 (EQH41_05260) 991564..991920 + 357 WP_000817623.1 SAG1252 family conjugative relaxosome accessory protein -
EQH41_RS04935 (EQH41_05265) 991925..992290 + 366 WP_000401239.1 MobC family plasmid mobilization relaxosome protein -
EQH41_RS04940 (EQH41_05270) 992277..994100 + 1824 WP_000237143.1 SAG1250 family conjugative relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 968612..1022558 53946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29129.20 Da        Isoelectric Point: 7.5087

>T117441 WP_000405360.1 NZ_CP035239:988787-989548 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Download         Length: 762 bp

>T117441 NZ_CP035239:988787-989548 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
CACACGAAAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTCTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
CAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18247.70 Da        Isoelectric Point: 4.4188

>AT117441 WP_000579608.1 NZ_CP035239:988311-988787 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQLEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT117441 NZ_CP035239:988311-988787 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTGCGTAAAACACATGACTTAACACAACTCGAATTTGCACGGATTGTAGGTATTTC
ACGAAATAGTCTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
GTCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGATTTGATTCATACGAATATCTATCTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGTGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTGGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2P5T

Antitoxin

Source ID Structure

References